DDX3 modulates the tumor microenvironment via its role in endoplasmic reticulum-associated translation

Using antibody arrays, we found that the RNA helicase DDX3 modulates the expression of secreted signaling factors in oral squamous cell carcinoma (OSCC) cells. Ribo-seq analysis confirmed amphiregulin (AREG) as a translational target of DDX3. AREG exerts important biological functions in cancer, inc...

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Detalles Bibliográficos
Autores principales: Chen, Hung-Hsi, Yu, Hsin-I, Rudy, Rudy, Lim, Sim-Lin, Chen, Yi-Fen, Wu, Shu-Hsing, Lin, Shu-Chun, Yang, Muh-Hwa, Tarn, Woan-Yuh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449240/
https://www.ncbi.nlm.nih.gov/pubmed/34568799
http://dx.doi.org/10.1016/j.isci.2021.103086

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