Structural and functional characterization of ubiquitin variant inhibitors for the JAMM-family deubiquitinases STAMBP and STAMBPL1

Ubiquitination is a crucial posttranslational protein modification involved in a myriad of biological pathways. This modification is reversed by deubiquitinases (DUBs) that deconjugate the single ubiquitin (Ub) moiety or poly-Ub chains from substrates. In the past decade, tremendous efforts have bee...

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Detalles Bibliográficos
Autores principales: Guo, Yusong, Liu, Qi, Mallette, Evan, Caba, Cody, Hou, Feng, Fux, Julia, LaPlante, Gabriel, Dong, Aiping, Zhang, Qi, Zheng, Hui, Tong, Yufeng, Zhang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449267/
https://www.ncbi.nlm.nih.gov/pubmed/34425109
http://dx.doi.org/10.1016/j.jbc.2021.101107

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