Takes one to B1a: Dismantling the origin of mantle cell lymphoma

Therapeutic discovery for mantle cell lymphoma (MCL) has been hindered by a lack of preclinical mouse models that recapitulate human disease. In this issue, Pieters and colleagues (2021. J. Exp. Med. https://doi.org/10.1084/jem.20202280) establish a novel mouse model of MCL driven by overexpression...

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Detalles Bibliográficos
Autor principal: Beaudin, Anna E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449273/
https://www.ncbi.nlm.nih.gov/pubmed/34529750
http://dx.doi.org/10.1084/jem.20211482
Descripción
Sumario:Therapeutic discovery for mantle cell lymphoma (MCL) has been hindered by a lack of preclinical mouse models that recapitulate human disease. In this issue, Pieters and colleagues (2021. J. Exp. Med. https://doi.org/10.1084/jem.20202280) establish a novel mouse model of MCL driven by overexpression of cyclin D2 and identify fetal-derived B1a cells as putative cell of origin for MCL.

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