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Takes one to B1a: Dismantling the origin of mantle cell lymphoma
Therapeutic discovery for mantle cell lymphoma (MCL) has been hindered by a lack of preclinical mouse models that recapitulate human disease. In this issue, Pieters and colleagues (2021. J. Exp. Med. https://doi.org/10.1084/jem.20202280) establish a novel mouse model of MCL driven by overexpression...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Rockefeller University Press
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449273/ https://www.ncbi.nlm.nih.gov/pubmed/34529750 http://dx.doi.org/10.1084/jem.20211482 |
| _version_ | 1784569397798502400 |
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| author | Beaudin, Anna E. |
| author_facet | Beaudin, Anna E. |
| author_sort | Beaudin, Anna E. |
| collection | PubMed |
| description | Therapeutic discovery for mantle cell lymphoma (MCL) has been hindered by a lack of preclinical mouse models that recapitulate human disease. In this issue, Pieters and colleagues (2021. J. Exp. Med. https://doi.org/10.1084/jem.20202280) establish a novel mouse model of MCL driven by overexpression of cyclin D2 and identify fetal-derived B1a cells as putative cell of origin for MCL. |
| format | Online Article Text |
| id | pubmed-8449273 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Rockefeller University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-84492732022-04-04 Takes one to B1a: Dismantling the origin of mantle cell lymphoma Beaudin, Anna E. J Exp Med Insights Therapeutic discovery for mantle cell lymphoma (MCL) has been hindered by a lack of preclinical mouse models that recapitulate human disease. In this issue, Pieters and colleagues (2021. J. Exp. Med. https://doi.org/10.1084/jem.20202280) establish a novel mouse model of MCL driven by overexpression of cyclin D2 and identify fetal-derived B1a cells as putative cell of origin for MCL. Rockefeller University Press 2021-09-16 /pmc/articles/PMC8449273/ /pubmed/34529750 http://dx.doi.org/10.1084/jem.20211482 Text en © 2021 Beaudin http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). |
| spellingShingle | Insights Beaudin, Anna E. Takes one to B1a: Dismantling the origin of mantle cell lymphoma |
| title | Takes one to B1a: Dismantling the origin of mantle cell lymphoma |
| title_full | Takes one to B1a: Dismantling the origin of mantle cell lymphoma |
| title_fullStr | Takes one to B1a: Dismantling the origin of mantle cell lymphoma |
| title_full_unstemmed | Takes one to B1a: Dismantling the origin of mantle cell lymphoma |
| title_short | Takes one to B1a: Dismantling the origin of mantle cell lymphoma |
| title_sort | takes one to b1a: dismantling the origin of mantle cell lymphoma |
| topic | Insights |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449273/ https://www.ncbi.nlm.nih.gov/pubmed/34529750 http://dx.doi.org/10.1084/jem.20211482 |
| work_keys_str_mv | AT beaudinannae takesonetob1adismantlingtheoriginofmantlecelllymphoma |