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Comparative genomics provides insights into the aquatic adaptations of mammals
The ancestors of marine mammals once roamed the land and independently committed to an aquatic lifestyle. These macroevolutionary transitions have intrigued scientists for centuries. Here, we generated high-quality genome assemblies of 17 marine mammals (11 cetaceans and six pinnipeds), including ei...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449357/ https://www.ncbi.nlm.nih.gov/pubmed/34503999 http://dx.doi.org/10.1073/pnas.2106080118 |
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author | Yuan, Yuan Zhang, Yaolei Zhang, Peijun Liu, Chang Wang, Jiahao Gao, Haiyu Hoelzel, A. Rus Seim, Inge Lv, Meiqi Lin, Mingli Dong, Lijun Gao, Haoyang Yang, Zixin Caruso, Francesco Lin, Wenzhi da Fonseca, Rute R. Wang, Ding Wang, Xianyan Rasmussen, Marianne H. Liu, Mingming Zheng, Jinsong Zhao, Liyuan Campos, Paula F. Kang, Hui Iversen, Maria Song, Yue Guo, Xinyu Guo, Jiao Qin, Yating Pan, Shanshan Xu, Qiwu Meng, Lingfeng A, Yunga Liu, Shanshan Lee, Simon Ming-Yuen Liu, Xin Xu, Xun Yang, Huanming Fan, Guangyi Wang, Kun Li, Songhai |
author_facet | Yuan, Yuan Zhang, Yaolei Zhang, Peijun Liu, Chang Wang, Jiahao Gao, Haiyu Hoelzel, A. Rus Seim, Inge Lv, Meiqi Lin, Mingli Dong, Lijun Gao, Haoyang Yang, Zixin Caruso, Francesco Lin, Wenzhi da Fonseca, Rute R. Wang, Ding Wang, Xianyan Rasmussen, Marianne H. Liu, Mingming Zheng, Jinsong Zhao, Liyuan Campos, Paula F. Kang, Hui Iversen, Maria Song, Yue Guo, Xinyu Guo, Jiao Qin, Yating Pan, Shanshan Xu, Qiwu Meng, Lingfeng A, Yunga Liu, Shanshan Lee, Simon Ming-Yuen Liu, Xin Xu, Xun Yang, Huanming Fan, Guangyi Wang, Kun Li, Songhai |
author_sort | Yuan, Yuan |
collection | PubMed |
description | The ancestors of marine mammals once roamed the land and independently committed to an aquatic lifestyle. These macroevolutionary transitions have intrigued scientists for centuries. Here, we generated high-quality genome assemblies of 17 marine mammals (11 cetaceans and six pinnipeds), including eight assemblies at the chromosome level. Incorporating previously published data, we reconstructed the marine mammal phylogeny and population histories and identified numerous idiosyncratic and convergent genomic variations that possibly contributed to the transition from land to water in marine mammal lineages. Genes associated with the formation of blubber (NFIA), vascular development (SEMA3E), and heat production by brown adipose tissue (UCP1) had unique changes that may contribute to marine mammal thermoregulation. We also observed many lineage-specific changes in the marine mammals, including genes associated with deep diving and navigation. Our study advances understanding of the timing, pattern, and molecular changes associated with the evolution of mammalian lineages adapting to aquatic life. |
format | Online Article Text |
id | pubmed-8449357 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | National Academy of Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-84493572021-10-04 Comparative genomics provides insights into the aquatic adaptations of mammals Yuan, Yuan Zhang, Yaolei Zhang, Peijun Liu, Chang Wang, Jiahao Gao, Haiyu Hoelzel, A. Rus Seim, Inge Lv, Meiqi Lin, Mingli Dong, Lijun Gao, Haoyang Yang, Zixin Caruso, Francesco Lin, Wenzhi da Fonseca, Rute R. Wang, Ding Wang, Xianyan Rasmussen, Marianne H. Liu, Mingming Zheng, Jinsong Zhao, Liyuan Campos, Paula F. Kang, Hui Iversen, Maria Song, Yue Guo, Xinyu Guo, Jiao Qin, Yating Pan, Shanshan Xu, Qiwu Meng, Lingfeng A, Yunga Liu, Shanshan Lee, Simon Ming-Yuen Liu, Xin Xu, Xun Yang, Huanming Fan, Guangyi Wang, Kun Li, Songhai Proc Natl Acad Sci U S A Biological Sciences The ancestors of marine mammals once roamed the land and independently committed to an aquatic lifestyle. These macroevolutionary transitions have intrigued scientists for centuries. Here, we generated high-quality genome assemblies of 17 marine mammals (11 cetaceans and six pinnipeds), including eight assemblies at the chromosome level. Incorporating previously published data, we reconstructed the marine mammal phylogeny and population histories and identified numerous idiosyncratic and convergent genomic variations that possibly contributed to the transition from land to water in marine mammal lineages. Genes associated with the formation of blubber (NFIA), vascular development (SEMA3E), and heat production by brown adipose tissue (UCP1) had unique changes that may contribute to marine mammal thermoregulation. We also observed many lineage-specific changes in the marine mammals, including genes associated with deep diving and navigation. Our study advances understanding of the timing, pattern, and molecular changes associated with the evolution of mammalian lineages adapting to aquatic life. National Academy of Sciences 2021-09-14 2021-09-09 /pmc/articles/PMC8449357/ /pubmed/34503999 http://dx.doi.org/10.1073/pnas.2106080118 Text en Copyright © 2021 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Biological Sciences Yuan, Yuan Zhang, Yaolei Zhang, Peijun Liu, Chang Wang, Jiahao Gao, Haiyu Hoelzel, A. Rus Seim, Inge Lv, Meiqi Lin, Mingli Dong, Lijun Gao, Haoyang Yang, Zixin Caruso, Francesco Lin, Wenzhi da Fonseca, Rute R. Wang, Ding Wang, Xianyan Rasmussen, Marianne H. Liu, Mingming Zheng, Jinsong Zhao, Liyuan Campos, Paula F. Kang, Hui Iversen, Maria Song, Yue Guo, Xinyu Guo, Jiao Qin, Yating Pan, Shanshan Xu, Qiwu Meng, Lingfeng A, Yunga Liu, Shanshan Lee, Simon Ming-Yuen Liu, Xin Xu, Xun Yang, Huanming Fan, Guangyi Wang, Kun Li, Songhai Comparative genomics provides insights into the aquatic adaptations of mammals |
title | Comparative genomics provides insights into the aquatic adaptations of mammals |
title_full | Comparative genomics provides insights into the aquatic adaptations of mammals |
title_fullStr | Comparative genomics provides insights into the aquatic adaptations of mammals |
title_full_unstemmed | Comparative genomics provides insights into the aquatic adaptations of mammals |
title_short | Comparative genomics provides insights into the aquatic adaptations of mammals |
title_sort | comparative genomics provides insights into the aquatic adaptations of mammals |
topic | Biological Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449357/ https://www.ncbi.nlm.nih.gov/pubmed/34503999 http://dx.doi.org/10.1073/pnas.2106080118 |
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