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Low physical activity is associated with impaired endothelial function in patients with type 2 diabetes and controls after 5 years of follow-up
BACKGROUND: The long-term association between physical activity and endothelial function has not previously been investigated in patients with type 2 diabetes. Therefore, we aimed to evaluate the relationship between physical activity and endothelial function, assessed by peripheral arterial tonomet...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449475/ https://www.ncbi.nlm.nih.gov/pubmed/34535107 http://dx.doi.org/10.1186/s12902-021-00857-9 |
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author | Baier, Jonathan Mathias Funck, Kristian Løkke Vernstrøm, Liv Laugesen, Esben Poulsen, Per Løgstrup |
author_facet | Baier, Jonathan Mathias Funck, Kristian Løkke Vernstrøm, Liv Laugesen, Esben Poulsen, Per Løgstrup |
author_sort | Baier, Jonathan Mathias |
collection | PubMed |
description | BACKGROUND: The long-term association between physical activity and endothelial function has not previously been investigated in patients with type 2 diabetes. Therefore, we aimed to evaluate the relationship between physical activity and endothelial function, assessed by peripheral arterial tonometry, in patients with type 2 diabetes and non-diabetic controls after 5 years of follow-up. METHODS: We included 51 patients with newly diagnosed type 2 diabetes and 53 sex- and age matched controls. Participants underwent baseline clinical characterization including objective measurement of physical activity level using accelerometery. After 5 years of follow-up, participants were re-examined, and endothelial function was assessed as natural logarithm of reactive hyperemia index (lnRHI). RESULTS: Physical activity at baseline was associated with lnRHI after 5 years of follow-up in both patients with type 2 diabetes and controls. An increase of 1 standard deviation (SD) in daytime physical activity corresponded to a 6.7 % increase in RHI (95 % confidence interval: 1.1;12.5 %, p = 0.02). We found no difference in lnRHI between patients with diabetes and controls (0.67 ± 0.29 vs. 0.73 ± 0.31, p = 0.28). CONCLUSIONS: Daytime physical activity is associated with endothelial function after 5 years of follow-up in patients with type 2 diabetes and controls. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12902-021-00857-9. |
format | Online Article Text |
id | pubmed-8449475 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-84494752021-09-20 Low physical activity is associated with impaired endothelial function in patients with type 2 diabetes and controls after 5 years of follow-up Baier, Jonathan Mathias Funck, Kristian Løkke Vernstrøm, Liv Laugesen, Esben Poulsen, Per Løgstrup BMC Endocr Disord Research BACKGROUND: The long-term association between physical activity and endothelial function has not previously been investigated in patients with type 2 diabetes. Therefore, we aimed to evaluate the relationship between physical activity and endothelial function, assessed by peripheral arterial tonometry, in patients with type 2 diabetes and non-diabetic controls after 5 years of follow-up. METHODS: We included 51 patients with newly diagnosed type 2 diabetes and 53 sex- and age matched controls. Participants underwent baseline clinical characterization including objective measurement of physical activity level using accelerometery. After 5 years of follow-up, participants were re-examined, and endothelial function was assessed as natural logarithm of reactive hyperemia index (lnRHI). RESULTS: Physical activity at baseline was associated with lnRHI after 5 years of follow-up in both patients with type 2 diabetes and controls. An increase of 1 standard deviation (SD) in daytime physical activity corresponded to a 6.7 % increase in RHI (95 % confidence interval: 1.1;12.5 %, p = 0.02). We found no difference in lnRHI between patients with diabetes and controls (0.67 ± 0.29 vs. 0.73 ± 0.31, p = 0.28). CONCLUSIONS: Daytime physical activity is associated with endothelial function after 5 years of follow-up in patients with type 2 diabetes and controls. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12902-021-00857-9. BioMed Central 2021-09-18 /pmc/articles/PMC8449475/ /pubmed/34535107 http://dx.doi.org/10.1186/s12902-021-00857-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Baier, Jonathan Mathias Funck, Kristian Løkke Vernstrøm, Liv Laugesen, Esben Poulsen, Per Løgstrup Low physical activity is associated with impaired endothelial function in patients with type 2 diabetes and controls after 5 years of follow-up |
title | Low physical activity is associated with impaired endothelial function in patients with type 2 diabetes and controls after 5 years of follow-up |
title_full | Low physical activity is associated with impaired endothelial function in patients with type 2 diabetes and controls after 5 years of follow-up |
title_fullStr | Low physical activity is associated with impaired endothelial function in patients with type 2 diabetes and controls after 5 years of follow-up |
title_full_unstemmed | Low physical activity is associated with impaired endothelial function in patients with type 2 diabetes and controls after 5 years of follow-up |
title_short | Low physical activity is associated with impaired endothelial function in patients with type 2 diabetes and controls after 5 years of follow-up |
title_sort | low physical activity is associated with impaired endothelial function in patients with type 2 diabetes and controls after 5 years of follow-up |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449475/ https://www.ncbi.nlm.nih.gov/pubmed/34535107 http://dx.doi.org/10.1186/s12902-021-00857-9 |
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