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Quality of Life Assessment and Pain Severity in Breast Cancer Patients Prior to Palliative Oncology Treatment in Indonesia: A Cross-Sectional Study

PURPOSE: Studies assessing quality of life (QOL) in palliative care settings are still scarce. We assessed the QOL score and pain severity in advanced breast cancer patients at the National Cancer Hospital in Indonesia and associations between QOL domains with QOL and pain scores. MATERIALS AND METH...

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Autores principales: Gayatri, Dwi, Efremov, Ljupcho, Mikolajczyk, Rafael, Kantelhardt, Eva Johanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449683/
https://www.ncbi.nlm.nih.gov/pubmed/34548783
http://dx.doi.org/10.2147/PPA.S320972
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author Gayatri, Dwi
Efremov, Ljupcho
Mikolajczyk, Rafael
Kantelhardt, Eva Johanna
author_facet Gayatri, Dwi
Efremov, Ljupcho
Mikolajczyk, Rafael
Kantelhardt, Eva Johanna
author_sort Gayatri, Dwi
collection PubMed
description PURPOSE: Studies assessing quality of life (QOL) in palliative care settings are still scarce. We assessed the QOL score and pain severity in advanced breast cancer patients at the National Cancer Hospital in Indonesia and associations between QOL domains with QOL and pain scores. MATERIALS AND METHODS: A total of 160 patients who met the study inclusion criteria (female, >18 years old, diagnosed with stage III or IV breast cancer) answered the European Organization for Research and Treatment of Cancer QOL questionnaire (EORTC QLQ-C15-PAL) and the visual analogue scale (VAS) tool for pain severity, prior to palliative oncology treatment. Additionally, several sociodemographic and clinical characteristics were collected. Linear regression models, adjusted for age, the Karnofsky Performance Status (KPS) score, and specific QOL domains were used to explore the associations between the global QOL and VAS scores with the different QOL domains. RESULTS: The patients had a mean age of 50 years (range: 29–76). The overall score for QOL and score for VAS was (mean ± SD) 78.02 ± 15.34 and 2.1 ± 2.4, respectively. The analysis demonstrated that the domains of emotional functioning (effect estimate: 0.25; 95% CI: 0.14 to 0.37), fatigue (−0.21; −0.33 to −0.09), pain (−0.13; −0.25 to −0.01), insomnia (−0.25; −0.37 to −0.13), and appetite loss (−0.13; −0.25 to −0.008) were associated with the QOL score. Only the KPS score (−0.28; −0.46 to −0.11) was associated with the VAS score. CONCLUSION: Our study showed high QOL and low VAS scores in advanced breast cancer patients prior to palliative oncology treatment. Several QOL domains (emotional functioning, fatigue, pain, insomnia, and appetite loss) were associated with QOL and the KPS was associated with the pain score. Therefore, these specific QOL domains should be given priority in improving QOL in this patient group.
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spelling pubmed-84496832021-09-20 Quality of Life Assessment and Pain Severity in Breast Cancer Patients Prior to Palliative Oncology Treatment in Indonesia: A Cross-Sectional Study Gayatri, Dwi Efremov, Ljupcho Mikolajczyk, Rafael Kantelhardt, Eva Johanna Patient Prefer Adherence Original Research PURPOSE: Studies assessing quality of life (QOL) in palliative care settings are still scarce. We assessed the QOL score and pain severity in advanced breast cancer patients at the National Cancer Hospital in Indonesia and associations between QOL domains with QOL and pain scores. MATERIALS AND METHODS: A total of 160 patients who met the study inclusion criteria (female, >18 years old, diagnosed with stage III or IV breast cancer) answered the European Organization for Research and Treatment of Cancer QOL questionnaire (EORTC QLQ-C15-PAL) and the visual analogue scale (VAS) tool for pain severity, prior to palliative oncology treatment. Additionally, several sociodemographic and clinical characteristics were collected. Linear regression models, adjusted for age, the Karnofsky Performance Status (KPS) score, and specific QOL domains were used to explore the associations between the global QOL and VAS scores with the different QOL domains. RESULTS: The patients had a mean age of 50 years (range: 29–76). The overall score for QOL and score for VAS was (mean ± SD) 78.02 ± 15.34 and 2.1 ± 2.4, respectively. The analysis demonstrated that the domains of emotional functioning (effect estimate: 0.25; 95% CI: 0.14 to 0.37), fatigue (−0.21; −0.33 to −0.09), pain (−0.13; −0.25 to −0.01), insomnia (−0.25; −0.37 to −0.13), and appetite loss (−0.13; −0.25 to −0.008) were associated with the QOL score. Only the KPS score (−0.28; −0.46 to −0.11) was associated with the VAS score. CONCLUSION: Our study showed high QOL and low VAS scores in advanced breast cancer patients prior to palliative oncology treatment. Several QOL domains (emotional functioning, fatigue, pain, insomnia, and appetite loss) were associated with QOL and the KPS was associated with the pain score. Therefore, these specific QOL domains should be given priority in improving QOL in this patient group. Dove 2021-09-14 /pmc/articles/PMC8449683/ /pubmed/34548783 http://dx.doi.org/10.2147/PPA.S320972 Text en © 2021 Gayatri et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Gayatri, Dwi
Efremov, Ljupcho
Mikolajczyk, Rafael
Kantelhardt, Eva Johanna
Quality of Life Assessment and Pain Severity in Breast Cancer Patients Prior to Palliative Oncology Treatment in Indonesia: A Cross-Sectional Study
title Quality of Life Assessment and Pain Severity in Breast Cancer Patients Prior to Palliative Oncology Treatment in Indonesia: A Cross-Sectional Study
title_full Quality of Life Assessment and Pain Severity in Breast Cancer Patients Prior to Palliative Oncology Treatment in Indonesia: A Cross-Sectional Study
title_fullStr Quality of Life Assessment and Pain Severity in Breast Cancer Patients Prior to Palliative Oncology Treatment in Indonesia: A Cross-Sectional Study
title_full_unstemmed Quality of Life Assessment and Pain Severity in Breast Cancer Patients Prior to Palliative Oncology Treatment in Indonesia: A Cross-Sectional Study
title_short Quality of Life Assessment and Pain Severity in Breast Cancer Patients Prior to Palliative Oncology Treatment in Indonesia: A Cross-Sectional Study
title_sort quality of life assessment and pain severity in breast cancer patients prior to palliative oncology treatment in indonesia: a cross-sectional study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449683/
https://www.ncbi.nlm.nih.gov/pubmed/34548783
http://dx.doi.org/10.2147/PPA.S320972
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