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Trimetazidine attenuates dexamethasone-induced muscle atrophy via inhibiting NLRP3/GSDMD pathway-mediated pyroptosis

Skeletal muscle atrophy is one of the major side effects of high dose or sustained usage of glucocorticoids. Pyroptosis is a novel form of pro-inflammatory programmed cell death that may contribute to skeletal muscle injury. Trimetazidine, a well-known anti-anginal agent, can improve skeletal muscle...

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Detalles Bibliográficos
Autores principales:	Wang, Li, Jiao, Xin-Feng, Wu, Cheng, Li, Xiao-Qing, Sun, Hui-Xian, Shen, Xi-Yu, Zhang, Kang-Zhen, Zhao, Can, Liu, Li, Wang, Man, Bu, Yun-Ling, Li, Jia-Wen, Xu, Fan, Chang, Chen-Lu, Lu, Xiang, Gao, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449784/ https://www.ncbi.nlm.nih.gov/pubmed/34537816 http://dx.doi.org/10.1038/s41420-021-00648-0

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