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Whole-Genome Sequencing of a 900-Year-Old Human Skeleton Supports Two Past Migration Events from the Russian Far East to Northern Japan

Recent studies on paleogenomics have reported some Paleolithic and Neolithic genomes that have provided new insights into the human population history in East and Northeast Asia. However, there remain some cases where more recent migration events need to be examined to elucidate the detailed formati...

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Autores principales: Sato, Takehiro, Adachi, Noboru, Kimura, Ryosuke, Hosomichi, Kazuyoshi, Yoneda, Minoru, Oota, Hiroki, Tajima, Atsushi, Toyoda, Atsushi, Kanzawa-Kiriyama, Hideaki, Matsumae, Hiromi, Koganebuchi, Kae, Shimizu, Kentaro K, Shinoda, Ken-ichi, Hanihara, Tsunehiko, Weber, Andrzej, Kato, Hirofumi, Ishida, Hajime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449830/
https://www.ncbi.nlm.nih.gov/pubmed/34410389
http://dx.doi.org/10.1093/gbe/evab192
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author Sato, Takehiro
Adachi, Noboru
Kimura, Ryosuke
Hosomichi, Kazuyoshi
Yoneda, Minoru
Oota, Hiroki
Tajima, Atsushi
Toyoda, Atsushi
Kanzawa-Kiriyama, Hideaki
Matsumae, Hiromi
Koganebuchi, Kae
Shimizu, Kentaro K
Shinoda, Ken-ichi
Hanihara, Tsunehiko
Weber, Andrzej
Kato, Hirofumi
Ishida, Hajime
author_facet Sato, Takehiro
Adachi, Noboru
Kimura, Ryosuke
Hosomichi, Kazuyoshi
Yoneda, Minoru
Oota, Hiroki
Tajima, Atsushi
Toyoda, Atsushi
Kanzawa-Kiriyama, Hideaki
Matsumae, Hiromi
Koganebuchi, Kae
Shimizu, Kentaro K
Shinoda, Ken-ichi
Hanihara, Tsunehiko
Weber, Andrzej
Kato, Hirofumi
Ishida, Hajime
author_sort Sato, Takehiro
collection PubMed
description Recent studies on paleogenomics have reported some Paleolithic and Neolithic genomes that have provided new insights into the human population history in East and Northeast Asia. However, there remain some cases where more recent migration events need to be examined to elucidate the detailed formation process of local populations. Although the area around northern Japan is one of the regions archaeologically suggested to have been affected by migration waves after the Neolithic period, the genetic source of these migrations are still unclear. Thus, genomic data from such past migrant populations would be highly informative to clarify the detailed formation process of local populations in this region. Here, we report the genome sequence of a 900-year-old adult female (NAT002) belonging to the prehistoric Okhotsk people, who have been considered to be the past migrants to northern Japan after the Neolithic period. We found a close relationship between NAT002 and modern Lower Amur populations and past admixture events between the Amur, Jomon, and Kamchatka ancestries. The admixture dating suggested migration of Amur-related ancestry at approximately 1,600 BP, which is compatible with the archaeological evidence regarding the settlement of the Okhotsk people. Our results also imply migration of Kamchatka-related ancestry at approximately 2,000 BP. In addition, human leukocyte antigen (HLA) typing detected the HLA-B*40 allele, which is reported to increase the risk of arthritis, suggesting the genetic vulnerability of NAT002 to hyperostosis, which was observed around her chest clavicle.
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spelling pubmed-84498302021-09-20 Whole-Genome Sequencing of a 900-Year-Old Human Skeleton Supports Two Past Migration Events from the Russian Far East to Northern Japan Sato, Takehiro Adachi, Noboru Kimura, Ryosuke Hosomichi, Kazuyoshi Yoneda, Minoru Oota, Hiroki Tajima, Atsushi Toyoda, Atsushi Kanzawa-Kiriyama, Hideaki Matsumae, Hiromi Koganebuchi, Kae Shimizu, Kentaro K Shinoda, Ken-ichi Hanihara, Tsunehiko Weber, Andrzej Kato, Hirofumi Ishida, Hajime Genome Biol Evol Research Article Recent studies on paleogenomics have reported some Paleolithic and Neolithic genomes that have provided new insights into the human population history in East and Northeast Asia. However, there remain some cases where more recent migration events need to be examined to elucidate the detailed formation process of local populations. Although the area around northern Japan is one of the regions archaeologically suggested to have been affected by migration waves after the Neolithic period, the genetic source of these migrations are still unclear. Thus, genomic data from such past migrant populations would be highly informative to clarify the detailed formation process of local populations in this region. Here, we report the genome sequence of a 900-year-old adult female (NAT002) belonging to the prehistoric Okhotsk people, who have been considered to be the past migrants to northern Japan after the Neolithic period. We found a close relationship between NAT002 and modern Lower Amur populations and past admixture events between the Amur, Jomon, and Kamchatka ancestries. The admixture dating suggested migration of Amur-related ancestry at approximately 1,600 BP, which is compatible with the archaeological evidence regarding the settlement of the Okhotsk people. Our results also imply migration of Kamchatka-related ancestry at approximately 2,000 BP. In addition, human leukocyte antigen (HLA) typing detected the HLA-B*40 allele, which is reported to increase the risk of arthritis, suggesting the genetic vulnerability of NAT002 to hyperostosis, which was observed around her chest clavicle. Oxford University Press 2021-08-19 /pmc/articles/PMC8449830/ /pubmed/34410389 http://dx.doi.org/10.1093/gbe/evab192 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sato, Takehiro
Adachi, Noboru
Kimura, Ryosuke
Hosomichi, Kazuyoshi
Yoneda, Minoru
Oota, Hiroki
Tajima, Atsushi
Toyoda, Atsushi
Kanzawa-Kiriyama, Hideaki
Matsumae, Hiromi
Koganebuchi, Kae
Shimizu, Kentaro K
Shinoda, Ken-ichi
Hanihara, Tsunehiko
Weber, Andrzej
Kato, Hirofumi
Ishida, Hajime
Whole-Genome Sequencing of a 900-Year-Old Human Skeleton Supports Two Past Migration Events from the Russian Far East to Northern Japan
title Whole-Genome Sequencing of a 900-Year-Old Human Skeleton Supports Two Past Migration Events from the Russian Far East to Northern Japan
title_full Whole-Genome Sequencing of a 900-Year-Old Human Skeleton Supports Two Past Migration Events from the Russian Far East to Northern Japan
title_fullStr Whole-Genome Sequencing of a 900-Year-Old Human Skeleton Supports Two Past Migration Events from the Russian Far East to Northern Japan
title_full_unstemmed Whole-Genome Sequencing of a 900-Year-Old Human Skeleton Supports Two Past Migration Events from the Russian Far East to Northern Japan
title_short Whole-Genome Sequencing of a 900-Year-Old Human Skeleton Supports Two Past Migration Events from the Russian Far East to Northern Japan
title_sort whole-genome sequencing of a 900-year-old human skeleton supports two past migration events from the russian far east to northern japan
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449830/
https://www.ncbi.nlm.nih.gov/pubmed/34410389
http://dx.doi.org/10.1093/gbe/evab192
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