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First detected case of rabbit Haemorrhagic disease virus 2 (RHDV2) in the Irish hare (Lepus timidus hibernicus)

BACKGROUND: Rabbit haemorrhagic disease virus (RHDV) is a Lagovirus, a subgroup of the family Caliciviridae. RHDV2 is a variant first described in France in 2010, and has since spread globally. It has been reported in several Lagomorph species (rabbits, hares, and their relatives) as well as other m...

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Autores principales: Kennedy, Aideen, Britton, Louise, Byrne, Andrew W., Byrne, Christina, Casey, Mícheál, Flynn, Orla, Lozano, Jose Maria, Marnell, Ferdia, McElroy, Maire, Reid, Neil, Wilson, Margaret, FitzGerald, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449885/
https://www.ncbi.nlm.nih.gov/pubmed/34537065
http://dx.doi.org/10.1186/s13620-021-00205-2
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author Kennedy, Aideen
Britton, Louise
Byrne, Andrew W.
Byrne, Christina
Casey, Mícheál
Flynn, Orla
Lozano, Jose Maria
Marnell, Ferdia
McElroy, Maire
Reid, Neil
Wilson, Margaret
FitzGerald, William
author_facet Kennedy, Aideen
Britton, Louise
Byrne, Andrew W.
Byrne, Christina
Casey, Mícheál
Flynn, Orla
Lozano, Jose Maria
Marnell, Ferdia
McElroy, Maire
Reid, Neil
Wilson, Margaret
FitzGerald, William
author_sort Kennedy, Aideen
collection PubMed
description BACKGROUND: Rabbit haemorrhagic disease virus (RHDV) is a Lagovirus, a subgroup of the family Caliciviridae. RHDV2 is a variant first described in France in 2010, and has since spread globally. It has been reported in several Lagomorph species (rabbits, hares, and their relatives) as well as other mammals including voles and shrews. The disease has raised international concerns for its potential impact on population abundance trajectories, particularly as 25% of Lagomorphs are currently Red-Listed by the International Union for the Conservation of Nature (IUCN). The Irish hare (Lepus timidus hibernicus) is a subspecies of the mountain hare, L. timidus, and is endemic to Ireland, making it an Evolutionarily Significant Unit of intrinsic value. CASE PRESENTATION: The first case of RHDV2 was detected in a wild Irish hare in July 2019. The individual exhibited atypical neurological behaviour (running in circles) prior to death. On necropsy, pink tinged foam was seen in the trachea and congestion was noted in the lungs, but there was no evidence of haemorrhages in any other organ. Both the liver and spleen were tested by reverse transcription real time qPCR confirming high levels of RHDV2 RNA. Histopathology confirmed multifocal necrotising hepatitis. CONCLUSION: The Irish hare is susceptible to RHDV2 infection. Further investigation is warranted to explore the clinical, epidemiological, and population biology implications.
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spelling pubmed-84498852021-09-20 First detected case of rabbit Haemorrhagic disease virus 2 (RHDV2) in the Irish hare (Lepus timidus hibernicus) Kennedy, Aideen Britton, Louise Byrne, Andrew W. Byrne, Christina Casey, Mícheál Flynn, Orla Lozano, Jose Maria Marnell, Ferdia McElroy, Maire Reid, Neil Wilson, Margaret FitzGerald, William Ir Vet J Case Report BACKGROUND: Rabbit haemorrhagic disease virus (RHDV) is a Lagovirus, a subgroup of the family Caliciviridae. RHDV2 is a variant first described in France in 2010, and has since spread globally. It has been reported in several Lagomorph species (rabbits, hares, and their relatives) as well as other mammals including voles and shrews. The disease has raised international concerns for its potential impact on population abundance trajectories, particularly as 25% of Lagomorphs are currently Red-Listed by the International Union for the Conservation of Nature (IUCN). The Irish hare (Lepus timidus hibernicus) is a subspecies of the mountain hare, L. timidus, and is endemic to Ireland, making it an Evolutionarily Significant Unit of intrinsic value. CASE PRESENTATION: The first case of RHDV2 was detected in a wild Irish hare in July 2019. The individual exhibited atypical neurological behaviour (running in circles) prior to death. On necropsy, pink tinged foam was seen in the trachea and congestion was noted in the lungs, but there was no evidence of haemorrhages in any other organ. Both the liver and spleen were tested by reverse transcription real time qPCR confirming high levels of RHDV2 RNA. Histopathology confirmed multifocal necrotising hepatitis. CONCLUSION: The Irish hare is susceptible to RHDV2 infection. Further investigation is warranted to explore the clinical, epidemiological, and population biology implications. BioMed Central 2021-09-18 /pmc/articles/PMC8449885/ /pubmed/34537065 http://dx.doi.org/10.1186/s13620-021-00205-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Kennedy, Aideen
Britton, Louise
Byrne, Andrew W.
Byrne, Christina
Casey, Mícheál
Flynn, Orla
Lozano, Jose Maria
Marnell, Ferdia
McElroy, Maire
Reid, Neil
Wilson, Margaret
FitzGerald, William
First detected case of rabbit Haemorrhagic disease virus 2 (RHDV2) in the Irish hare (Lepus timidus hibernicus)
title First detected case of rabbit Haemorrhagic disease virus 2 (RHDV2) in the Irish hare (Lepus timidus hibernicus)
title_full First detected case of rabbit Haemorrhagic disease virus 2 (RHDV2) in the Irish hare (Lepus timidus hibernicus)
title_fullStr First detected case of rabbit Haemorrhagic disease virus 2 (RHDV2) in the Irish hare (Lepus timidus hibernicus)
title_full_unstemmed First detected case of rabbit Haemorrhagic disease virus 2 (RHDV2) in the Irish hare (Lepus timidus hibernicus)
title_short First detected case of rabbit Haemorrhagic disease virus 2 (RHDV2) in the Irish hare (Lepus timidus hibernicus)
title_sort first detected case of rabbit haemorrhagic disease virus 2 (rhdv2) in the irish hare (lepus timidus hibernicus)
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449885/
https://www.ncbi.nlm.nih.gov/pubmed/34537065
http://dx.doi.org/10.1186/s13620-021-00205-2
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