Cargando…

Plasma zinc status and hyperinflammatory syndrome in hospitalized COVID-19 patients: An observational study

Zinc deficiency is associated with impaired antiviral response, cytokine releasing syndrome (CRS), and acute respiratory distress syndrome. Notably, similar complications are being observed during severe SARS-CoV-2 infection. We conducted a prospective, single-center, observational study in a tertia...

Descripción completa

Detalles Bibliográficos
Autores principales: Verschelden, Gil, Noeparast, Maxim, Noparast, Maryam, Goossens, Mathijs Christiaan, Lauwers, Maïlis, Cotton, Frédéric, Michel, Charlotte, Goyvaerts, Cleo, Hites, Maya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450071/
https://www.ncbi.nlm.nih.gov/pubmed/34583122
http://dx.doi.org/10.1016/j.intimp.2021.108163
_version_ 1784569548340461568
author Verschelden, Gil
Noeparast, Maxim
Noparast, Maryam
Goossens, Mathijs Christiaan
Lauwers, Maïlis
Cotton, Frédéric
Michel, Charlotte
Goyvaerts, Cleo
Hites, Maya
author_facet Verschelden, Gil
Noeparast, Maxim
Noparast, Maryam
Goossens, Mathijs Christiaan
Lauwers, Maïlis
Cotton, Frédéric
Michel, Charlotte
Goyvaerts, Cleo
Hites, Maya
author_sort Verschelden, Gil
collection PubMed
description Zinc deficiency is associated with impaired antiviral response, cytokine releasing syndrome (CRS), and acute respiratory distress syndrome. Notably, similar complications are being observed during severe SARS-CoV-2 infection. We conducted a prospective, single-center, observational study in a tertiary university hospital (CUB-Hôpital Erasme, Brussels) to address the zinc status, the association between the plasma zinc concentration, development of CRS, and the clinical outcomes in PCR-confirmed and hospitalized COVID-19 patients. One hundred and thirty-nine eligible patients were included between May 2020 and November 2020 (median age of 65 years [IQR = 54, 77]). Our cohort's median plasma zinc concentration was 57 µg/dL (interquartile range [IQR] = 45, 67) compared to 74 µg/dL (IQR = 64, 84) in the retrospective non-COVID-19 control group (N = 1513; p < 0.001). Markedly, the absolute majority of COVID-19 patients (96%) were zinc deficient (<80 µg/dL). The median zinc concentration was lower in patients with CRS compared to those without CRS (-5 µg/dL; 95% CI = -10.5, 0.051; p = 0.048). Among the tested outcomes, zinc concentration is significantly correlated with only the length of hospital stay (rho = -0.19; p = 0.022), but not with mortality or morbidity. As such, our findings do not support the role of zinc as a robust prognostic marker among hospitalized COVID-19 patients who in our cohort presented a high prevalence of zinc deficiency. It might be more beneficial to explore the role of zinc as a biomarker for assessing the risk of developing a tissue-damaging CRS and predicting outcomes in patients diagnosed with COVID-19 at the early stage of the disease.
format Online
Article
Text
id pubmed-8450071
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier B.V.
record_format MEDLINE/PubMed
spelling pubmed-84500712021-09-20 Plasma zinc status and hyperinflammatory syndrome in hospitalized COVID-19 patients: An observational study Verschelden, Gil Noeparast, Maxim Noparast, Maryam Goossens, Mathijs Christiaan Lauwers, Maïlis Cotton, Frédéric Michel, Charlotte Goyvaerts, Cleo Hites, Maya Int Immunopharmacol Article Zinc deficiency is associated with impaired antiviral response, cytokine releasing syndrome (CRS), and acute respiratory distress syndrome. Notably, similar complications are being observed during severe SARS-CoV-2 infection. We conducted a prospective, single-center, observational study in a tertiary university hospital (CUB-Hôpital Erasme, Brussels) to address the zinc status, the association between the plasma zinc concentration, development of CRS, and the clinical outcomes in PCR-confirmed and hospitalized COVID-19 patients. One hundred and thirty-nine eligible patients were included between May 2020 and November 2020 (median age of 65 years [IQR = 54, 77]). Our cohort's median plasma zinc concentration was 57 µg/dL (interquartile range [IQR] = 45, 67) compared to 74 µg/dL (IQR = 64, 84) in the retrospective non-COVID-19 control group (N = 1513; p < 0.001). Markedly, the absolute majority of COVID-19 patients (96%) were zinc deficient (<80 µg/dL). The median zinc concentration was lower in patients with CRS compared to those without CRS (-5 µg/dL; 95% CI = -10.5, 0.051; p = 0.048). Among the tested outcomes, zinc concentration is significantly correlated with only the length of hospital stay (rho = -0.19; p = 0.022), but not with mortality or morbidity. As such, our findings do not support the role of zinc as a robust prognostic marker among hospitalized COVID-19 patients who in our cohort presented a high prevalence of zinc deficiency. It might be more beneficial to explore the role of zinc as a biomarker for assessing the risk of developing a tissue-damaging CRS and predicting outcomes in patients diagnosed with COVID-19 at the early stage of the disease. Elsevier B.V. 2021-11 2021-09-20 /pmc/articles/PMC8450071/ /pubmed/34583122 http://dx.doi.org/10.1016/j.intimp.2021.108163 Text en © 2021 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Verschelden, Gil
Noeparast, Maxim
Noparast, Maryam
Goossens, Mathijs Christiaan
Lauwers, Maïlis
Cotton, Frédéric
Michel, Charlotte
Goyvaerts, Cleo
Hites, Maya
Plasma zinc status and hyperinflammatory syndrome in hospitalized COVID-19 patients: An observational study
title Plasma zinc status and hyperinflammatory syndrome in hospitalized COVID-19 patients: An observational study
title_full Plasma zinc status and hyperinflammatory syndrome in hospitalized COVID-19 patients: An observational study
title_fullStr Plasma zinc status and hyperinflammatory syndrome in hospitalized COVID-19 patients: An observational study
title_full_unstemmed Plasma zinc status and hyperinflammatory syndrome in hospitalized COVID-19 patients: An observational study
title_short Plasma zinc status and hyperinflammatory syndrome in hospitalized COVID-19 patients: An observational study
title_sort plasma zinc status and hyperinflammatory syndrome in hospitalized covid-19 patients: an observational study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450071/
https://www.ncbi.nlm.nih.gov/pubmed/34583122
http://dx.doi.org/10.1016/j.intimp.2021.108163
work_keys_str_mv AT verscheldengil plasmazincstatusandhyperinflammatorysyndromeinhospitalizedcovid19patientsanobservationalstudy
AT noeparastmaxim plasmazincstatusandhyperinflammatorysyndromeinhospitalizedcovid19patientsanobservationalstudy
AT noparastmaryam plasmazincstatusandhyperinflammatorysyndromeinhospitalizedcovid19patientsanobservationalstudy
AT goossensmathijschristiaan plasmazincstatusandhyperinflammatorysyndromeinhospitalizedcovid19patientsanobservationalstudy
AT lauwersmailis plasmazincstatusandhyperinflammatorysyndromeinhospitalizedcovid19patientsanobservationalstudy
AT cottonfrederic plasmazincstatusandhyperinflammatorysyndromeinhospitalizedcovid19patientsanobservationalstudy
AT michelcharlotte plasmazincstatusandhyperinflammatorysyndromeinhospitalizedcovid19patientsanobservationalstudy
AT goyvaertscleo plasmazincstatusandhyperinflammatorysyndromeinhospitalizedcovid19patientsanobservationalstudy
AT hitesmaya plasmazincstatusandhyperinflammatorysyndromeinhospitalizedcovid19patientsanobservationalstudy