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Plasma zinc status and hyperinflammatory syndrome in hospitalized COVID-19 patients: An observational study
Zinc deficiency is associated with impaired antiviral response, cytokine releasing syndrome (CRS), and acute respiratory distress syndrome. Notably, similar complications are being observed during severe SARS-CoV-2 infection. We conducted a prospective, single-center, observational study in a tertia...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450071/ https://www.ncbi.nlm.nih.gov/pubmed/34583122 http://dx.doi.org/10.1016/j.intimp.2021.108163 |
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author | Verschelden, Gil Noeparast, Maxim Noparast, Maryam Goossens, Mathijs Christiaan Lauwers, Maïlis Cotton, Frédéric Michel, Charlotte Goyvaerts, Cleo Hites, Maya |
author_facet | Verschelden, Gil Noeparast, Maxim Noparast, Maryam Goossens, Mathijs Christiaan Lauwers, Maïlis Cotton, Frédéric Michel, Charlotte Goyvaerts, Cleo Hites, Maya |
author_sort | Verschelden, Gil |
collection | PubMed |
description | Zinc deficiency is associated with impaired antiviral response, cytokine releasing syndrome (CRS), and acute respiratory distress syndrome. Notably, similar complications are being observed during severe SARS-CoV-2 infection. We conducted a prospective, single-center, observational study in a tertiary university hospital (CUB-Hôpital Erasme, Brussels) to address the zinc status, the association between the plasma zinc concentration, development of CRS, and the clinical outcomes in PCR-confirmed and hospitalized COVID-19 patients. One hundred and thirty-nine eligible patients were included between May 2020 and November 2020 (median age of 65 years [IQR = 54, 77]). Our cohort's median plasma zinc concentration was 57 µg/dL (interquartile range [IQR] = 45, 67) compared to 74 µg/dL (IQR = 64, 84) in the retrospective non-COVID-19 control group (N = 1513; p < 0.001). Markedly, the absolute majority of COVID-19 patients (96%) were zinc deficient (<80 µg/dL). The median zinc concentration was lower in patients with CRS compared to those without CRS (-5 µg/dL; 95% CI = -10.5, 0.051; p = 0.048). Among the tested outcomes, zinc concentration is significantly correlated with only the length of hospital stay (rho = -0.19; p = 0.022), but not with mortality or morbidity. As such, our findings do not support the role of zinc as a robust prognostic marker among hospitalized COVID-19 patients who in our cohort presented a high prevalence of zinc deficiency. It might be more beneficial to explore the role of zinc as a biomarker for assessing the risk of developing a tissue-damaging CRS and predicting outcomes in patients diagnosed with COVID-19 at the early stage of the disease. |
format | Online Article Text |
id | pubmed-8450071 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84500712021-09-20 Plasma zinc status and hyperinflammatory syndrome in hospitalized COVID-19 patients: An observational study Verschelden, Gil Noeparast, Maxim Noparast, Maryam Goossens, Mathijs Christiaan Lauwers, Maïlis Cotton, Frédéric Michel, Charlotte Goyvaerts, Cleo Hites, Maya Int Immunopharmacol Article Zinc deficiency is associated with impaired antiviral response, cytokine releasing syndrome (CRS), and acute respiratory distress syndrome. Notably, similar complications are being observed during severe SARS-CoV-2 infection. We conducted a prospective, single-center, observational study in a tertiary university hospital (CUB-Hôpital Erasme, Brussels) to address the zinc status, the association between the plasma zinc concentration, development of CRS, and the clinical outcomes in PCR-confirmed and hospitalized COVID-19 patients. One hundred and thirty-nine eligible patients were included between May 2020 and November 2020 (median age of 65 years [IQR = 54, 77]). Our cohort's median plasma zinc concentration was 57 µg/dL (interquartile range [IQR] = 45, 67) compared to 74 µg/dL (IQR = 64, 84) in the retrospective non-COVID-19 control group (N = 1513; p < 0.001). Markedly, the absolute majority of COVID-19 patients (96%) were zinc deficient (<80 µg/dL). The median zinc concentration was lower in patients with CRS compared to those without CRS (-5 µg/dL; 95% CI = -10.5, 0.051; p = 0.048). Among the tested outcomes, zinc concentration is significantly correlated with only the length of hospital stay (rho = -0.19; p = 0.022), but not with mortality or morbidity. As such, our findings do not support the role of zinc as a robust prognostic marker among hospitalized COVID-19 patients who in our cohort presented a high prevalence of zinc deficiency. It might be more beneficial to explore the role of zinc as a biomarker for assessing the risk of developing a tissue-damaging CRS and predicting outcomes in patients diagnosed with COVID-19 at the early stage of the disease. Elsevier B.V. 2021-11 2021-09-20 /pmc/articles/PMC8450071/ /pubmed/34583122 http://dx.doi.org/10.1016/j.intimp.2021.108163 Text en © 2021 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Verschelden, Gil Noeparast, Maxim Noparast, Maryam Goossens, Mathijs Christiaan Lauwers, Maïlis Cotton, Frédéric Michel, Charlotte Goyvaerts, Cleo Hites, Maya Plasma zinc status and hyperinflammatory syndrome in hospitalized COVID-19 patients: An observational study |
title | Plasma zinc status and hyperinflammatory syndrome in hospitalized COVID-19 patients: An observational study |
title_full | Plasma zinc status and hyperinflammatory syndrome in hospitalized COVID-19 patients: An observational study |
title_fullStr | Plasma zinc status and hyperinflammatory syndrome in hospitalized COVID-19 patients: An observational study |
title_full_unstemmed | Plasma zinc status and hyperinflammatory syndrome in hospitalized COVID-19 patients: An observational study |
title_short | Plasma zinc status and hyperinflammatory syndrome in hospitalized COVID-19 patients: An observational study |
title_sort | plasma zinc status and hyperinflammatory syndrome in hospitalized covid-19 patients: an observational study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450071/ https://www.ncbi.nlm.nih.gov/pubmed/34583122 http://dx.doi.org/10.1016/j.intimp.2021.108163 |
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