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Cooperative DNA binding mediated by KicGAS/ORF52 oligomerization allows inhibition of DNA-induced phase separation and activation of cGAS

Cyclic GMP-AMP synthase (cGAS) is a key DNA sensor that detects aberrant cytosolic DNA arising from pathogen invasions or genotoxic stresses. Upon binding to DNA, cGAS is activated and catalyzes the synthesis of cyclic GMP-AMP (cGAMP), which induces potent antimicrobial and antitumor responses. Kapo...

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Detalles Bibliográficos
Autores principales:	Bhowmik, Debipreeta, Du, Mingjian, Tian, Yuan, Ma, Siming, Wu, Jianjun, Chen, Zhijian, Yin, Qian, Zhu, Fanxiu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450086/ https://www.ncbi.nlm.nih.gov/pubmed/34387695 http://dx.doi.org/10.1093/nar/gkab689

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