Protein cofactors and substrate influence Mg(2+)-dependent structural changes in the catalytic RNA of archaeal RNase P

The ribonucleoprotein (RNP) form of archaeal RNase P comprises one catalytic RNA and five protein cofactors. To catalyze Mg(2+)-dependent cleavage of the 5′ leader from pre-tRNAs, the catalytic (C) and specificity (S) domains of the RNase P RNA (RPR) cooperate to recognize different parts of the pre...

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Detalles Bibliográficos
Autores principales: Marathe, Ila A, Lai, Stella M, Zahurancik, Walter J, Poirier, Michael G, Wysocki, Vicki H, Gopalan, Venkat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450104/
https://www.ncbi.nlm.nih.gov/pubmed/34387688
http://dx.doi.org/10.1093/nar/gkab655

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