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Computational resources to define alleles and altered regulatory motifs at genomically edited candidate response elements
Unequivocal functional assessment of candidate genomic regulatory regions, such as transcriptional response elements, requires genetic alteration at their native chromosomal loci. Targeted DNA cleavage by Cas9 or other programmable nucleases enables analysis at virtually any genomic region, and dive...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450113/ https://www.ncbi.nlm.nih.gov/pubmed/34417596 http://dx.doi.org/10.1093/nar/gkab700 |