A novel compound heterozygous leptin receptor mutation causes more severe obesity than in Lepr(db/db) mice

The leptin receptor (Lepr) pathway is important for food intake regulation, energy expenditure, and body weight. Mutations in leptin and the Lepr have been shown to cause early-onset severe obesity in mice and humans. In studies with C57BL/6NCrl mice, we found a mouse with extreme obesity. To identi...

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Detalles Bibliográficos
Autores principales: Berger, Claudia, Heyne, Henrike O., Heiland, Tina, Dommel, Sebastian, Höfling, Corinna, Guiu-Jurado, Esther, Lorenz, Jana, Roßner, Steffen, Dannemann, Michael, Kelso, Janet, Kovacs, Peter, Blüher, Matthias, Klöting, Nora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450258/
https://www.ncbi.nlm.nih.gov/pubmed/34390703
http://dx.doi.org/10.1016/j.jlr.2021.100105

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