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Brief Report: Case Comparison of Therapy With the Histone Deacetylase Inhibitor Vorinostat in a Neonatal Calf Model of Pulmonary Hypertension

Pulmonary hypertension (PH) is an incurable condition in humans; driven by pulmonary vascular remodeling partially mediated by epigenetic mechanisms; and leading to right ventricular hypertrophy, failure, and death. We hypothesized that targeting chromatin-modifying histone deacetylases may provide...

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Detalles Bibliográficos
Autores principales:	Applegate, Tanya J., Krafsur, Greta M., Boon, June A., Zhang, Hui, Li, Min, Holt, Timothy N., Ambler, S. Kelly, Abrams, Benjamin A., Gustafson, Daniel L., Bartels, Karsten, Garry, Franklyn B., Stenmark, Kurt R., Brown, R. Dale
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450341/ https://www.ncbi.nlm.nih.gov/pubmed/34552503 http://dx.doi.org/10.3389/fphys.2021.712583

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