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The Role of Large-Scale Data Infrastructure in Developing Next-Generation Deep Brain Stimulation Therapies

Advances in neuromodulation technologies hold the promise of treating a patient’s unique brain network pathology using personalized stimulation patterns. In service of these goals, neuromodulation clinical trials using sensing-enabled devices are routinely generating large multi-modal datasets. Howe...

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Autores principales: Chen, Witney, Kirkby, Lowry, Kotzev, Miro, Song, Patrick, Gilron, Ro’ee, Pepin, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450349/
https://www.ncbi.nlm.nih.gov/pubmed/34552476
http://dx.doi.org/10.3389/fnhum.2021.717401
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author Chen, Witney
Kirkby, Lowry
Kotzev, Miro
Song, Patrick
Gilron, Ro’ee
Pepin, Brian
author_facet Chen, Witney
Kirkby, Lowry
Kotzev, Miro
Song, Patrick
Gilron, Ro’ee
Pepin, Brian
author_sort Chen, Witney
collection PubMed
description Advances in neuromodulation technologies hold the promise of treating a patient’s unique brain network pathology using personalized stimulation patterns. In service of these goals, neuromodulation clinical trials using sensing-enabled devices are routinely generating large multi-modal datasets. However, with the expansion of data acquisition also comes an increasing difficulty to store, manage, and analyze the associated datasets, which integrate complex neural and wearable time-series data with dynamic assessments of patients’ symptomatic state. Here, we discuss a scalable cloud-based data platform that enables ingestion, aggregation, storage, query, and analysis of multi-modal neurotechnology datasets. This large-scale data infrastructure will accelerate translational neuromodulation research and enable the development and delivery of next-generation deep brain stimulation therapies.
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spelling pubmed-84503492021-09-21 The Role of Large-Scale Data Infrastructure in Developing Next-Generation Deep Brain Stimulation Therapies Chen, Witney Kirkby, Lowry Kotzev, Miro Song, Patrick Gilron, Ro’ee Pepin, Brian Front Hum Neurosci Human Neuroscience Advances in neuromodulation technologies hold the promise of treating a patient’s unique brain network pathology using personalized stimulation patterns. In service of these goals, neuromodulation clinical trials using sensing-enabled devices are routinely generating large multi-modal datasets. However, with the expansion of data acquisition also comes an increasing difficulty to store, manage, and analyze the associated datasets, which integrate complex neural and wearable time-series data with dynamic assessments of patients’ symptomatic state. Here, we discuss a scalable cloud-based data platform that enables ingestion, aggregation, storage, query, and analysis of multi-modal neurotechnology datasets. This large-scale data infrastructure will accelerate translational neuromodulation research and enable the development and delivery of next-generation deep brain stimulation therapies. Frontiers Media S.A. 2021-09-06 /pmc/articles/PMC8450349/ /pubmed/34552476 http://dx.doi.org/10.3389/fnhum.2021.717401 Text en Copyright © 2021 Chen, Kirkby, Kotzev, Song, Gilron and Pepin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Human Neuroscience
Chen, Witney
Kirkby, Lowry
Kotzev, Miro
Song, Patrick
Gilron, Ro’ee
Pepin, Brian
The Role of Large-Scale Data Infrastructure in Developing Next-Generation Deep Brain Stimulation Therapies
title The Role of Large-Scale Data Infrastructure in Developing Next-Generation Deep Brain Stimulation Therapies
title_full The Role of Large-Scale Data Infrastructure in Developing Next-Generation Deep Brain Stimulation Therapies
title_fullStr The Role of Large-Scale Data Infrastructure in Developing Next-Generation Deep Brain Stimulation Therapies
title_full_unstemmed The Role of Large-Scale Data Infrastructure in Developing Next-Generation Deep Brain Stimulation Therapies
title_short The Role of Large-Scale Data Infrastructure in Developing Next-Generation Deep Brain Stimulation Therapies
title_sort role of large-scale data infrastructure in developing next-generation deep brain stimulation therapies
topic Human Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450349/
https://www.ncbi.nlm.nih.gov/pubmed/34552476
http://dx.doi.org/10.3389/fnhum.2021.717401
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