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The Role of Large-Scale Data Infrastructure in Developing Next-Generation Deep Brain Stimulation Therapies
Advances in neuromodulation technologies hold the promise of treating a patient’s unique brain network pathology using personalized stimulation patterns. In service of these goals, neuromodulation clinical trials using sensing-enabled devices are routinely generating large multi-modal datasets. Howe...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450349/ https://www.ncbi.nlm.nih.gov/pubmed/34552476 http://dx.doi.org/10.3389/fnhum.2021.717401 |
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author | Chen, Witney Kirkby, Lowry Kotzev, Miro Song, Patrick Gilron, Ro’ee Pepin, Brian |
author_facet | Chen, Witney Kirkby, Lowry Kotzev, Miro Song, Patrick Gilron, Ro’ee Pepin, Brian |
author_sort | Chen, Witney |
collection | PubMed |
description | Advances in neuromodulation technologies hold the promise of treating a patient’s unique brain network pathology using personalized stimulation patterns. In service of these goals, neuromodulation clinical trials using sensing-enabled devices are routinely generating large multi-modal datasets. However, with the expansion of data acquisition also comes an increasing difficulty to store, manage, and analyze the associated datasets, which integrate complex neural and wearable time-series data with dynamic assessments of patients’ symptomatic state. Here, we discuss a scalable cloud-based data platform that enables ingestion, aggregation, storage, query, and analysis of multi-modal neurotechnology datasets. This large-scale data infrastructure will accelerate translational neuromodulation research and enable the development and delivery of next-generation deep brain stimulation therapies. |
format | Online Article Text |
id | pubmed-8450349 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84503492021-09-21 The Role of Large-Scale Data Infrastructure in Developing Next-Generation Deep Brain Stimulation Therapies Chen, Witney Kirkby, Lowry Kotzev, Miro Song, Patrick Gilron, Ro’ee Pepin, Brian Front Hum Neurosci Human Neuroscience Advances in neuromodulation technologies hold the promise of treating a patient’s unique brain network pathology using personalized stimulation patterns. In service of these goals, neuromodulation clinical trials using sensing-enabled devices are routinely generating large multi-modal datasets. However, with the expansion of data acquisition also comes an increasing difficulty to store, manage, and analyze the associated datasets, which integrate complex neural and wearable time-series data with dynamic assessments of patients’ symptomatic state. Here, we discuss a scalable cloud-based data platform that enables ingestion, aggregation, storage, query, and analysis of multi-modal neurotechnology datasets. This large-scale data infrastructure will accelerate translational neuromodulation research and enable the development and delivery of next-generation deep brain stimulation therapies. Frontiers Media S.A. 2021-09-06 /pmc/articles/PMC8450349/ /pubmed/34552476 http://dx.doi.org/10.3389/fnhum.2021.717401 Text en Copyright © 2021 Chen, Kirkby, Kotzev, Song, Gilron and Pepin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Human Neuroscience Chen, Witney Kirkby, Lowry Kotzev, Miro Song, Patrick Gilron, Ro’ee Pepin, Brian The Role of Large-Scale Data Infrastructure in Developing Next-Generation Deep Brain Stimulation Therapies |
title | The Role of Large-Scale Data Infrastructure in Developing Next-Generation Deep Brain Stimulation Therapies |
title_full | The Role of Large-Scale Data Infrastructure in Developing Next-Generation Deep Brain Stimulation Therapies |
title_fullStr | The Role of Large-Scale Data Infrastructure in Developing Next-Generation Deep Brain Stimulation Therapies |
title_full_unstemmed | The Role of Large-Scale Data Infrastructure in Developing Next-Generation Deep Brain Stimulation Therapies |
title_short | The Role of Large-Scale Data Infrastructure in Developing Next-Generation Deep Brain Stimulation Therapies |
title_sort | role of large-scale data infrastructure in developing next-generation deep brain stimulation therapies |
topic | Human Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450349/ https://www.ncbi.nlm.nih.gov/pubmed/34552476 http://dx.doi.org/10.3389/fnhum.2021.717401 |
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