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Understanding the Exchange of Systemic HDL Particles Into the Brain and Vascular Cells Has Diagnostic and Therapeutic Implications for Neurodegenerative Diseases

High-density lipoproteins (HDLs) are complex, heterogenous lipoprotein particles, consisting of a large family of apolipoproteins, formed in subspecies of distinct shapes, sizes, and functions and are synthesized in both the brain and the periphery. HDL apolipoproteins are important determinants of...

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Autores principales: Van Valkenburgh, Juno, Meuret, Cristiana, Martinez, Ashley E., Kodancha, Vibha, Solomon, Victoria, Chen, Kai, Yassine, Hussein N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450374/
https://www.ncbi.nlm.nih.gov/pubmed/34552500
http://dx.doi.org/10.3389/fphys.2021.700847
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author Van Valkenburgh, Juno
Meuret, Cristiana
Martinez, Ashley E.
Kodancha, Vibha
Solomon, Victoria
Chen, Kai
Yassine, Hussein N.
author_facet Van Valkenburgh, Juno
Meuret, Cristiana
Martinez, Ashley E.
Kodancha, Vibha
Solomon, Victoria
Chen, Kai
Yassine, Hussein N.
author_sort Van Valkenburgh, Juno
collection PubMed
description High-density lipoproteins (HDLs) are complex, heterogenous lipoprotein particles, consisting of a large family of apolipoproteins, formed in subspecies of distinct shapes, sizes, and functions and are synthesized in both the brain and the periphery. HDL apolipoproteins are important determinants of Alzheimer’s disease (AD) pathology and vascular dementia, having both central and peripheral effects on brain amyloid-beta (Aβ) accumulation and vascular functions, however, the extent to which HDL particles (HLD-P) can exchange their protein and lipid components between the central nervous system (CNS) and the systemic circulation remains unclear. In this review, we delineate how HDL’s structure and composition enable exchange between the brain, cerebrospinal fluid (CSF) compartment, and vascular cells that ultimately affect brain amyloid metabolism and atherosclerosis. Accordingly, we then elucidate how modifications of HDL-P have diagnostic and therapeutic potential for brain vascular and neurodegenerative diseases.
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spelling pubmed-84503742021-09-21 Understanding the Exchange of Systemic HDL Particles Into the Brain and Vascular Cells Has Diagnostic and Therapeutic Implications for Neurodegenerative Diseases Van Valkenburgh, Juno Meuret, Cristiana Martinez, Ashley E. Kodancha, Vibha Solomon, Victoria Chen, Kai Yassine, Hussein N. Front Physiol Physiology High-density lipoproteins (HDLs) are complex, heterogenous lipoprotein particles, consisting of a large family of apolipoproteins, formed in subspecies of distinct shapes, sizes, and functions and are synthesized in both the brain and the periphery. HDL apolipoproteins are important determinants of Alzheimer’s disease (AD) pathology and vascular dementia, having both central and peripheral effects on brain amyloid-beta (Aβ) accumulation and vascular functions, however, the extent to which HDL particles (HLD-P) can exchange their protein and lipid components between the central nervous system (CNS) and the systemic circulation remains unclear. In this review, we delineate how HDL’s structure and composition enable exchange between the brain, cerebrospinal fluid (CSF) compartment, and vascular cells that ultimately affect brain amyloid metabolism and atherosclerosis. Accordingly, we then elucidate how modifications of HDL-P have diagnostic and therapeutic potential for brain vascular and neurodegenerative diseases. Frontiers Media S.A. 2021-09-06 /pmc/articles/PMC8450374/ /pubmed/34552500 http://dx.doi.org/10.3389/fphys.2021.700847 Text en Copyright © 2021 Van Valkenburgh, Meuret, Martinez, Kodancha, Solomon, Chen and Yassine. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Van Valkenburgh, Juno
Meuret, Cristiana
Martinez, Ashley E.
Kodancha, Vibha
Solomon, Victoria
Chen, Kai
Yassine, Hussein N.
Understanding the Exchange of Systemic HDL Particles Into the Brain and Vascular Cells Has Diagnostic and Therapeutic Implications for Neurodegenerative Diseases
title Understanding the Exchange of Systemic HDL Particles Into the Brain and Vascular Cells Has Diagnostic and Therapeutic Implications for Neurodegenerative Diseases
title_full Understanding the Exchange of Systemic HDL Particles Into the Brain and Vascular Cells Has Diagnostic and Therapeutic Implications for Neurodegenerative Diseases
title_fullStr Understanding the Exchange of Systemic HDL Particles Into the Brain and Vascular Cells Has Diagnostic and Therapeutic Implications for Neurodegenerative Diseases
title_full_unstemmed Understanding the Exchange of Systemic HDL Particles Into the Brain and Vascular Cells Has Diagnostic and Therapeutic Implications for Neurodegenerative Diseases
title_short Understanding the Exchange of Systemic HDL Particles Into the Brain and Vascular Cells Has Diagnostic and Therapeutic Implications for Neurodegenerative Diseases
title_sort understanding the exchange of systemic hdl particles into the brain and vascular cells has diagnostic and therapeutic implications for neurodegenerative diseases
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450374/
https://www.ncbi.nlm.nih.gov/pubmed/34552500
http://dx.doi.org/10.3389/fphys.2021.700847
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