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Erythropoietin and Non-Erythropoietic Derivatives in Cognition
Cognitive deficits are widespread in psychiatric disorders, including major depression and schizophrenia. These deficits are known to contribute significantly to the accompanying functional impairment. Progress in the development of targeted treatments of cognitive deficits has been limited and ther...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450392/ https://www.ncbi.nlm.nih.gov/pubmed/34552490 http://dx.doi.org/10.3389/fphar.2021.728725 |
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author | Newton, Samuel S. Sathyanesan, Monica |
author_facet | Newton, Samuel S. Sathyanesan, Monica |
author_sort | Newton, Samuel S. |
collection | PubMed |
description | Cognitive deficits are widespread in psychiatric disorders, including major depression and schizophrenia. These deficits are known to contribute significantly to the accompanying functional impairment. Progress in the development of targeted treatments of cognitive deficits has been limited and there exists a major unmet need to develop more efficacious treatments. Erythropoietin (Epo) has shown promising procognitive effects in psychiatric disorders, providing support for a neurotrophic drug development approach. Several preclinical studies with non-erythropoietic derivatives have demonstrated that the modulation of behavior is independent of erythropoiesis. In this review, we examine the molecular, cellular and cognitive actions of Epo and non-erythropoietic molecular derivatives by focusing on their neurotrophic, synaptic, myelin plasticity, anti-inflammatory and neurogenic mechanisms in the brain. We also discuss the role of receptor signaling in Epo and non-erythropoietic EPO-mimetic molecules in their procognitive effects. |
format | Online Article Text |
id | pubmed-8450392 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84503922021-09-21 Erythropoietin and Non-Erythropoietic Derivatives in Cognition Newton, Samuel S. Sathyanesan, Monica Front Pharmacol Pharmacology Cognitive deficits are widespread in psychiatric disorders, including major depression and schizophrenia. These deficits are known to contribute significantly to the accompanying functional impairment. Progress in the development of targeted treatments of cognitive deficits has been limited and there exists a major unmet need to develop more efficacious treatments. Erythropoietin (Epo) has shown promising procognitive effects in psychiatric disorders, providing support for a neurotrophic drug development approach. Several preclinical studies with non-erythropoietic derivatives have demonstrated that the modulation of behavior is independent of erythropoiesis. In this review, we examine the molecular, cellular and cognitive actions of Epo and non-erythropoietic molecular derivatives by focusing on their neurotrophic, synaptic, myelin plasticity, anti-inflammatory and neurogenic mechanisms in the brain. We also discuss the role of receptor signaling in Epo and non-erythropoietic EPO-mimetic molecules in their procognitive effects. Frontiers Media S.A. 2021-09-06 /pmc/articles/PMC8450392/ /pubmed/34552490 http://dx.doi.org/10.3389/fphar.2021.728725 Text en Copyright © 2021 Newton and Sathyanesan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Newton, Samuel S. Sathyanesan, Monica Erythropoietin and Non-Erythropoietic Derivatives in Cognition |
title | Erythropoietin and Non-Erythropoietic Derivatives in Cognition |
title_full | Erythropoietin and Non-Erythropoietic Derivatives in Cognition |
title_fullStr | Erythropoietin and Non-Erythropoietic Derivatives in Cognition |
title_full_unstemmed | Erythropoietin and Non-Erythropoietic Derivatives in Cognition |
title_short | Erythropoietin and Non-Erythropoietic Derivatives in Cognition |
title_sort | erythropoietin and non-erythropoietic derivatives in cognition |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450392/ https://www.ncbi.nlm.nih.gov/pubmed/34552490 http://dx.doi.org/10.3389/fphar.2021.728725 |
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