Cargando…

Structural Analysis of SARS-CoV-2 ORF8 Protein: Pathogenic and Therapeutic Implications

Current therapeutic strategies and vaccines against SARS-CoV-2 are mainly focused on the Spike protein despite there are other viral proteins with important roles in COVID-19 pathogenicity. For example, ORF8 restructures vesicular trafficking in the host cell, impacts intracellular immunity through...

Descripción completa

Detalles Bibliográficos
Autores principales:	Valcarcel, Antonio, Bensussen, Antonio, Álvarez-Buylla, Elena R., Díaz, José
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450498/ https://www.ncbi.nlm.nih.gov/pubmed/34552615 http://dx.doi.org/10.3389/fgene.2021.693227

Ejemplares similares

ORF8 and Health Complications of COVID-19 in Down Syndrome Patients
por: Bensussen, Antonio, et al.
Publicado: (2022)

ORF8/ORF8a: a difference between SARS-CoV-2 and SARS-CoV
por: Zandi, Milad
Publicado: (2022)

SARS-CoV-2 ORF8 and SARS-CoV ORF8ab: Genomic Divergence and Functional Convergence
por: Mohammad, Sameer, et al.
Publicado: (2020)

Sequence similarity of SARS-CoV-2 and humans: Implications for SARS-CoV-2 detection
por: Li, Heng, et al.
Publicado: (2022)

Molecular and Biochemical Characterization of the SARS-CoV Accessory Proteins ORF8a, ORF8b and ORF8ab
por: Keng, Choong-Tat, et al.
Publicado: (2009)

Molecular tracking of insulin resistance and inflammation development on visceral adipose tissue
por: Bensussen, Antonio, et al.
Publicado: (2023)

Comprehensive Profiling Analysis of CD209 in Malignancies Reveals the Therapeutic Implication for Tumor Patients Infected With SARS-CoV-2
por: Li, Jinyuan, et al.
Publicado: (2022)

The ORF8 Protein of SARS-CoV-2 Modulates the Spike Protein and Its Implications in Viral Transmission
por: Chou, Jen-Mei, et al.
Publicado: (2022)

Lost in deletion: The enigmatic ORF8 protein of SARS-CoV-2
por: Zinzula, Luca
Publicado: (2021)

Immune evasion via SARS-CoV-2 ORF8 protein?
por: Park, Matthew D.
Publicado: (2020)

Evolutionary dynamics of the SARS-CoV-2 ORF8 accessory gene
por: Pereira, Filipe
Publicado: (2020)

ORF8a as a viroporin in SARS-CoV-2 infection?
por: Zandi, Milad
Publicado: (2021)

Epigenetic Regulator miRNA Pattern Differences Among SARS-CoV, SARS-CoV-2, and SARS-CoV-2 World-Wide Isolates Delineated the Mystery Behind the Epic Pathogenicity and Distinct Clinical Characteristics of Pandemic COVID-19
por: Khan, Md. Abdullah-Al-Kamran, et al.
Publicado: (2020)

Structure of SARS-CoV-2 ORF8, a rapidly evolving coronavirus protein implicated in immune evasion
por: Flower, Thomas G., et al.
Publicado: (2020)

A unique view of SARS-CoV-2 through the lens of ORF8 protein
por: Hassan, Sk Sarif, et al.
Publicado: (2021)

Viral Mimicry of Interleukin-17A by SARS-CoV-2 ORF8
por: Wu, Xin, et al.
Publicado: (2022)

SARS-CoV-2 ORF8 accessory protein is a virulence factor
por: Bello-Perez, M., et al.
Publicado: (2023)

COVID-DeepPredictor: Recurrent Neural Network to Predict SARS-CoV-2 and Other Pathogenic Viruses
por: Saha, Indrajit, et al.
Publicado: (2021)

The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway
por: Li, Jin-Yan, et al.
Publicado: (2020)

Insights into the SARS-CoV-2 ORF6 Mechanism of Action
por: Krachmarova, Elena, et al.
Publicado: (2023)

Pathogenic perspective of missense mutations of ORF3a protein of SARS-CoV-2
por: Hassan, Sk. Sarif, et al.
Publicado: (2021)

Hotspot Mutations in SARS-CoV-2
por: Saha, Indrajit, et al.
Publicado: (2021)

In silico Analysis of SARS-CoV-2 ORF8-Binding Proteins Reveals the Involvement of ORF8 in Acquired-Immune and Innate-Immune Systems
por: Takatsuka, Hisashi, et al.
Publicado: (2022)

SARS-CoV-2 variants lacking ORF8 occurred in farmed mink and pangolin
por: Pereira, Filipe
Publicado: (2021)

An issue of concern: unique truncated ORF8 protein variants of SARS-CoV-2
por: Hassan, Sk. Sarif, et al.
Publicado: (2022)

SARS-CoV-2–encoded ORF8 protein possesses complement inhibitory properties
por: Kumar, Jitendra, et al.
Publicado: (2023)

Characterization of the SARS-CoV-2 co-receptor NRP1 expression profiles in healthy people and cancer patients: Implication for susceptibility to COVID-19 disease and potential therapeutic strategy
por: Huang, Yongbiao, et al.
Publicado: (2022)

A Computational Model of the Endothelial to Mesenchymal Transition
por: Weinstein, Nathan, et al.
Publicado: (2020)

Predicting the Animal Susceptibility and Therapeutic Drugs to SARS-CoV-2 Based on Spike Glycoprotein Combined With ACE2
por: Shen, Min, et al.
Publicado: (2020)

Author Correction: ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection
por: Hachim, Asmaa, et al.
Publicado: (2020)

Conjugation with 8-arm PEG and CRM(197) enhances the immunogenicity of SARS-CoV-2 ORF8 protein
por: Tang, Xiaozhao, et al.
Publicado: (2022)

Structural Insights on the SARS-CoV-2 Variants of Concern Spike Glycoprotein: A Computational Study With Possible Clinical Implications
por: Cueno, Marni E., et al.
Publicado: (2021)

ORF8a of SARS-CoV forms an ion channel: Experiments and molecular dynamics simulations
por: Chen, Cheng-Chang, et al.
Publicado: (2011)

SARS-CoV-2 accessory protein ORF8 is secreted extracellularly as a glycoprotein homodimer
por: Matsuoka, Kazuhiro, et al.
Publicado: (2022)

Structure of SARS-CoV-2 ORF8, a rapidly evolving immune evasion protein
por: Flower, Thomas G., et al.
Publicado: (2021)

SARS-CoV-2 Accessory Protein ORF8 Decreases Antibody-Dependent Cellular Cytotoxicity
por: Beaudoin-Bussières, Guillaume, et al.
Publicado: (2022)

SARS-CoV-2 ORF8: One protein, seemingly one structure, and many functions
por: Vinjamuri, Smita, et al.
Publicado: (2022)

The 29-nucleotide deletion in SARS-CoV: truncated versions of ORF8 are under purifying selection
por: Bykova, Anastassia, et al.
Publicado: (2023)

Clinical characteristics and host immunity responses of SARS-CoV-2 Omicron variant BA.2 with deletion of ORF7a, ORF7b and ORF8
por: Tang, Zhizhong, et al.
Publicado: (2023)

Current HLA Investigations on SARS-CoV-2 and Perspectives
por: Douillard, Venceslas, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_lmes93ct509cdn7mb3t6vhv0q1