Bruton’s Tyrosine Kinase-Mediated Signaling in Myeloid Cells Is Required for Protective Innate Immunity During Pneumococcal Pneumonia

Bruton’s tyrosine kinase (Btk) is a cytoplasmic kinase expressed in B cells and myeloid cells. It is essential for B cell development and natural antibody-mediated host defense against bacteria in humans and mice, but little is known about the role of Btk in innate host defense in vivo. Previous stu...

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Detalles Bibliográficos
Autores principales: de Porto, Alexander P., Liu, Zhe, de Beer, Regina, Florquin, Sandrine, Roelofs, Joris J. T. H., de Boer, Onno J., den Haan, Joke M. M., Hendriks, Rudi W., van ‘t Veer, Cornelis, van der Poll, Tom, de Vos, Alex F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450579/
https://www.ncbi.nlm.nih.gov/pubmed/34552589
http://dx.doi.org/10.3389/fimmu.2021.723967

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