Cargando…

The antidepressant Sertraline inhibits CatSper Ca(2+) channels in human sperm

STUDY QUESTION: Do selective serotonin reuptake inhibitor (SSRI) antidepressants affect the function of human sperm? SUMMARY ANSWER: The SSRI antidepressant Sertraline (e.g. Zoloft) inhibits the sperm-specific Ca(2+) channel CatSper and affects human sperm function in vitro. WHAT IS KNOWN ALREADY: I...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rahban, Rita, Rehfeld, Anders, Schiffer, Christian, Brenker, Christoph, Egeberg Palme, Dorte Louise, Wang, Tao, Lorenz, Johannes, Almstrup, Kristian, Skakkebaek, Niels E, Strünker, Timo, Nef, Serge
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450872/ https://www.ncbi.nlm.nih.gov/pubmed/34486673 http://dx.doi.org/10.1093/humrep/deab190

Ejemplares similares

The action of physiological and synthetic steroids on the calcium channel CatSper in human sperm
por: Wehrli, Lydia, et al.
Publicado: (2023)

Rotational motion and rheotaxis of human sperm do not require functional CatSper channels and transmembrane Ca(2+) signaling
por: Schiffer, Christian, et al.
Publicado: (2020)

Lupeol and pristimerin do not inhibit activation of the human sperm CatSper Ca(2+)-channel
por: Rehfeld, Anders, et al.
Publicado: (2022)

Bisphenol A Diglycidyl Ether (BADGE) and Bisphenol Analogs, but Not Bisphenol A (BPA), Activate the CatSper Ca(2+) Channel in Human Sperm
por: Rehfeld, Anders, et al.
Publicado: (2020)

The Action of Reproductive Fluids and Contained Steroids, Prostaglandins, and Zn(2+) on CatSper Ca(2+) Channels in Human Sperm
por: Jeschke, Janice K., et al.
Publicado: (2021)

The Chemosensing Role of CatSper in Mammalian Sperm: An Updated Review
por: Ke, Sulun, et al.
Publicado: (2023)

Panax ginseng induces the expression of CatSper genes and sperm hyperactivation
por: Park, Eun Hwa, et al.
Publicado: (2014)

SKF96365 modulates activity of CatSper channels in human sperm
por: Torrezan-Nitao, Elis, et al.
Publicado: (2023)

Evolutionary Genomics Reveals Lineage-Specific Gene Loss and Rapid Evolution of a Sperm-Specific Ion Channel Complex: CatSpers and CatSperβ
por: Cai, Xinjiang, et al.
Publicado: (2008)

CCR6 is required for ligand-induced CatSper activation in human sperm
por: Diao, Ruiying, et al.
Publicado: (2017)

3D structure and in situ arrangements of CatSper channel in the sperm flagellum
por: Zhao, Yanhe, et al.
Publicado: (2022)

CatSper mediates not only chemotactic behavior but also the motility of ascidian sperm
por: Kijima, Taiga, et al.
Publicado: (2023)

Up-regulation of CatSper genes family by selenium
por: Mohammadi, Shabnam, et al.
Publicado: (2009)

Effect of CatSper and Hv1 Channel Inhibition on Progesterone Stimulated Human Sperm
por: Keshtgar, Sara, et al.
Publicado: (2018)

Release of Porcine Sperm from Oviduct Cells is Stimulated by Progesterone and Requires CatSper
por: Machado, Sergio A., et al.
Publicado: (2019)

Conserved Mechanism of Bicarbonate-Induced Sensitization of CatSper Channels in Human and Mouse Sperm
por: Ferreira, Juan J., et al.
Publicado: (2021)

Identification of human and mouse CatSper3 and CatSper4 genes: Characterisation of a common interaction domain and evidence for expression in testis
por: Lobley, Anna, et al.
Publicado: (2003)

Effect of experimental hyperthyroidism on CatSper1 and CatSper2 genes expression in the seminiferous tubules of BALB/c mice: An experimental study
por: Sadeghi, Saeed, et al.
Publicado: (2020)

Structural evolution of CatSper1 in rodents is influenced by sperm competition, with effects on sperm swimming velocity
por: Vicens, Alberto, et al.
Publicado: (2014)

Increased mitochondrial activity upon CatSper channel activation is required for mouse sperm capacitation
por: Ferreira, Juan J., et al.
Publicado: (2021)

Molecular Evolution of CatSper in Mammals and Function of Sperm Hyperactivation in Gray Short-Tailed Opossum
por: Hwang, Jae Yeon, et al.
Publicado: (2021)

Competitive CatSper Activators of Progesterone from Rhynchosia volubilis
por: Xiang, Jin, et al.
Publicado: (2021)

Discovery and Characterization of Multiple Classes of Human CatSper Blockers
por: Carlson, Erick J., et al.
Publicado: (2022)

Pharmacological Targeting of Native CatSper Channels Reveals a Required Role in Maintenance of Sperm Hyperactivation
por: Carlson, Anne E., et al.
Publicado: (2009)

p,p′-DDE activates CatSper and compromises human sperm function at environmentally relevant concentrations
por: Tavares, Renata S., et al.
Publicado: (2013)

2-APB-potentiated channels amplify CatSper-induced Ca(2+) signals in human sperm
por: Lefièvre, Linda, et al.
Publicado: (2012)

Effects of Vitamin-E treatment on CatSper genes expression and sperm quality in the testis of the aging mouse
por: Mohammadi, Shabnam, et al.
Publicado: (2013)

CRISP1 as a novel CatSper regulator that modulates sperm motility and orientation during fertilization
por: Ernesto, Juan I., et al.
Publicado: (2015)

Alteration in CatSper1 and 2 genes expression, sperm parameters and testis histology in varicocelized rats
por: Soleimani, Maryam Zohour, et al.
Publicado: (2018)

Ca(2+) Signals Generated by CatSper and Ca(2+) Stores Regulate Different Behaviors in Human Sperm
por: Alasmari, Wardah, et al.
Publicado: (2013)

Inhibition of the CatSper Channel and NOX5 Enzyme Activity Affects the Functions of the Progesterone-Stimulated Human Sperm
por: Ghanbari, Hamideh, et al.
Publicado: (2018)

CatSperζ regulates the structural continuity of sperm Ca(2+) signaling domains and is required for normal fertility
por: Chung, Jean-Ju, et al.
Publicado: (2017)

Network model predicts that CatSper is the main Ca(2+) channel in the regulation of sea urchin sperm motility
por: Espinal-Enríquez, Jesús, et al.
Publicado: (2017)

The Cation/Calcium Channel of Sperm (CatSper): A Common Role Played Despite Inter-Species Variation?
por: Vicente-Carrillo, Alejandro, et al.
Publicado: (2023)

The Fungal Sexual Pheromone Sirenin Activates the Human CatSper Channel Complex
por: Syeda, Shameem Sultana, et al.
Publicado: (2015)

Homozygous in-frame deletion in CATSPERE in a man producing spermatozoa with loss of CatSper function and compromised fertilizing capacity
por: Brown, Sean G, et al.
Publicado: (2018)

A CUG-initiated CATSPERθ functions in the CatSper channel assembly and serves as a checkpoint for flagellar trafficking
por: Huang, Xiaofang, et al.
Publicado: (2023)

Specific loss of CatSper function is sufficient to compromise fertilizing capacity of human spermatozoa
por: Williams, Hannah L., et al.
Publicado: (2015)

Pharmacological Inactivation of CatSper Blocks Sperm Fertilizing Ability Independently of the Capacitation Status of the Cells: Implications for Non-hormonal Contraception
por: Curci, Ludmila, et al.
Publicado: (2021)

Hexane fraction of Prunus japonica thunb. Seed extract enhances boar sperm motility via CatSper ion channel
por: Cooray, Akila, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_8gl157cb01v63odlhu8p4b1um5