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SARS-CoV-2 infection in general practice in Ireland: a seroprevalence study
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody testing in community settings may help us better understand the immune response to this virus and, therefore, help guide public health efforts. AIM: To conduct a seroprevalence study of immunoglobulin G (IgG) antibodie...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royal College of General Practitioners
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450885/ https://www.ncbi.nlm.nih.gov/pubmed/34006528 http://dx.doi.org/10.3399/BJGPO.2021.0038 |
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author | O'Callaghan, Michael E Ryan, Elizabeth Walsh, Cathal Hayes, Peter Casey, Monica O'Dwyer, Pat Culhane, Aidan Duncan, John W Harrold, Pat Healy, Jarlath Kerin, Emmet Kelly, Eimear Hanrahan, Conor Lane, Ger P Lynch, Bernie Meaney, Paraic O'Connell, Billy Galvin, Jim Kennedy, Norelee Burke, Paul O'Connell, Nuala H Dunne, Colum P Glynn, Liam G |
author_facet | O'Callaghan, Michael E Ryan, Elizabeth Walsh, Cathal Hayes, Peter Casey, Monica O'Dwyer, Pat Culhane, Aidan Duncan, John W Harrold, Pat Healy, Jarlath Kerin, Emmet Kelly, Eimear Hanrahan, Conor Lane, Ger P Lynch, Bernie Meaney, Paraic O'Connell, Billy Galvin, Jim Kennedy, Norelee Burke, Paul O'Connell, Nuala H Dunne, Colum P Glynn, Liam G |
author_sort | O'Callaghan, Michael E |
collection | PubMed |
description | BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody testing in community settings may help us better understand the immune response to this virus and, therefore, help guide public health efforts. AIM: To conduct a seroprevalence study of immunoglobulin G (IgG) antibodies in Irish GP clinics. DESIGN & SETTING: Participants were 172 staff and 799 patients from 15 general practices in the Midwest region of Ireland. METHOD: This seroprevalence study utilised two manufacturers’ point-of-care (POC) SARS-CoV-2 immunoglobulin M (IgM)—IgG combined antibody tests, which were offered to patients and staff in general practice from 15 June to 10 July 2020. RESULTS: IgG seroprevalence was 12.6% in patients attending general practice and 11.1% in staff working in general practice, with administrative staff having the lowest seroprevalence at 2.5% and nursing staff having the highest at 17.6%. Previous symptoms suggestive of COVID-19 and history of a polymerase chain reaction (PCR) test were associated with higher seroprevalence. IgG antibodies were detected in approximately 80% of participants who had a previous PCR-confirmed infection. Average length of time between participants’ positive PCR test and positive IgG antibody test was 83 days. CONCLUSION: Patients and healthcare staff in general practice in Ireland had relatively high rates of IgG to SARS-CoV-2 compared with the national average between 15 June and 10 July 2020 (1.7%). Four-fifths of participants with a history of confirmed COVID-19 disease still had detectable antibodies an average of 12 weeks post-infection. While not proof of immunity, SARS-CoV-2 POC testing can be used to estimate IgG seroprevalence in general practice settings. |
format | Online Article Text |
id | pubmed-8450885 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Royal College of General Practitioners |
record_format | MEDLINE/PubMed |
spelling | pubmed-84508852021-10-06 SARS-CoV-2 infection in general practice in Ireland: a seroprevalence study O'Callaghan, Michael E Ryan, Elizabeth Walsh, Cathal Hayes, Peter Casey, Monica O'Dwyer, Pat Culhane, Aidan Duncan, John W Harrold, Pat Healy, Jarlath Kerin, Emmet Kelly, Eimear Hanrahan, Conor Lane, Ger P Lynch, Bernie Meaney, Paraic O'Connell, Billy Galvin, Jim Kennedy, Norelee Burke, Paul O'Connell, Nuala H Dunne, Colum P Glynn, Liam G BJGP Open Research BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody testing in community settings may help us better understand the immune response to this virus and, therefore, help guide public health efforts. AIM: To conduct a seroprevalence study of immunoglobulin G (IgG) antibodies in Irish GP clinics. DESIGN & SETTING: Participants were 172 staff and 799 patients from 15 general practices in the Midwest region of Ireland. METHOD: This seroprevalence study utilised two manufacturers’ point-of-care (POC) SARS-CoV-2 immunoglobulin M (IgM)—IgG combined antibody tests, which were offered to patients and staff in general practice from 15 June to 10 July 2020. RESULTS: IgG seroprevalence was 12.6% in patients attending general practice and 11.1% in staff working in general practice, with administrative staff having the lowest seroprevalence at 2.5% and nursing staff having the highest at 17.6%. Previous symptoms suggestive of COVID-19 and history of a polymerase chain reaction (PCR) test were associated with higher seroprevalence. IgG antibodies were detected in approximately 80% of participants who had a previous PCR-confirmed infection. Average length of time between participants’ positive PCR test and positive IgG antibody test was 83 days. CONCLUSION: Patients and healthcare staff in general practice in Ireland had relatively high rates of IgG to SARS-CoV-2 compared with the national average between 15 June and 10 July 2020 (1.7%). Four-fifths of participants with a history of confirmed COVID-19 disease still had detectable antibodies an average of 12 weeks post-infection. While not proof of immunity, SARS-CoV-2 POC testing can be used to estimate IgG seroprevalence in general practice settings. Royal College of General Practitioners 2021-06-30 /pmc/articles/PMC8450885/ /pubmed/34006528 http://dx.doi.org/10.3399/BJGPO.2021.0038 Text en Copyright © 2021, The Authors https://creativecommons.org/licenses/by/4.0/This article is Open Access: CC BY license (https://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Research O'Callaghan, Michael E Ryan, Elizabeth Walsh, Cathal Hayes, Peter Casey, Monica O'Dwyer, Pat Culhane, Aidan Duncan, John W Harrold, Pat Healy, Jarlath Kerin, Emmet Kelly, Eimear Hanrahan, Conor Lane, Ger P Lynch, Bernie Meaney, Paraic O'Connell, Billy Galvin, Jim Kennedy, Norelee Burke, Paul O'Connell, Nuala H Dunne, Colum P Glynn, Liam G SARS-CoV-2 infection in general practice in Ireland: a seroprevalence study |
title | SARS-CoV-2 infection in general practice in Ireland: a seroprevalence study |
title_full | SARS-CoV-2 infection in general practice in Ireland: a seroprevalence study |
title_fullStr | SARS-CoV-2 infection in general practice in Ireland: a seroprevalence study |
title_full_unstemmed | SARS-CoV-2 infection in general practice in Ireland: a seroprevalence study |
title_short | SARS-CoV-2 infection in general practice in Ireland: a seroprevalence study |
title_sort | sars-cov-2 infection in general practice in ireland: a seroprevalence study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450885/ https://www.ncbi.nlm.nih.gov/pubmed/34006528 http://dx.doi.org/10.3399/BJGPO.2021.0038 |
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