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Strategies for the synthesis of brevipolides
In recent years fifteen 5,6-dihydro-α-pyrone derivatives, bearing either a distinctive cyclopropane or furan ring and named brevipolides A–O (1–15), have been isolated from the invasive plant Hyptis brevipes Poit. Their fascinating structural features, and the potent biological activities, including...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Beilstein-Institut
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450957/ https://www.ncbi.nlm.nih.gov/pubmed/34621402 http://dx.doi.org/10.3762/bjoc.17.157 |
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author | Kurniawan, Yudhi Dwi Rosyidah, A'liyatur |
author_facet | Kurniawan, Yudhi Dwi Rosyidah, A'liyatur |
author_sort | Kurniawan, Yudhi Dwi |
collection | PubMed |
description | In recent years fifteen 5,6-dihydro-α-pyrone derivatives, bearing either a distinctive cyclopropane or furan ring and named brevipolides A–O (1–15), have been isolated from the invasive plant Hyptis brevipes Poit. Their fascinating structural features, and the potent biological activities, including cytotoxicity against an array of human cancer cell lines and inhibition of the chemokine receptor CCR5, make them attractive synthetic targets. This review article highlights the recent synthetic methodologies and briefly summarizes their biological activities. |
format | Online Article Text |
id | pubmed-8450957 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Beilstein-Institut |
record_format | MEDLINE/PubMed |
spelling | pubmed-84509572021-10-06 Strategies for the synthesis of brevipolides Kurniawan, Yudhi Dwi Rosyidah, A'liyatur Beilstein J Org Chem Review In recent years fifteen 5,6-dihydro-α-pyrone derivatives, bearing either a distinctive cyclopropane or furan ring and named brevipolides A–O (1–15), have been isolated from the invasive plant Hyptis brevipes Poit. Their fascinating structural features, and the potent biological activities, including cytotoxicity against an array of human cancer cell lines and inhibition of the chemokine receptor CCR5, make them attractive synthetic targets. This review article highlights the recent synthetic methodologies and briefly summarizes their biological activities. Beilstein-Institut 2021-09-14 /pmc/articles/PMC8450957/ /pubmed/34621402 http://dx.doi.org/10.3762/bjoc.17.157 Text en Copyright © 2021, Kurniawan and Rosyidah https://creativecommons.org/licenses/by/4.0/https://www.beilstein-journals.org/bjoc/terms/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ). Please note that the reuse, redistribution and reproduction in particular requires that the author(s) and source are credited and that individual graphics may be subject to special legal provisions. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms/terms) |
spellingShingle | Review Kurniawan, Yudhi Dwi Rosyidah, A'liyatur Strategies for the synthesis of brevipolides |
title | Strategies for the synthesis of brevipolides |
title_full | Strategies for the synthesis of brevipolides |
title_fullStr | Strategies for the synthesis of brevipolides |
title_full_unstemmed | Strategies for the synthesis of brevipolides |
title_short | Strategies for the synthesis of brevipolides |
title_sort | strategies for the synthesis of brevipolides |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450957/ https://www.ncbi.nlm.nih.gov/pubmed/34621402 http://dx.doi.org/10.3762/bjoc.17.157 |
work_keys_str_mv | AT kurniawanyudhidwi strategiesforthesynthesisofbrevipolides AT rosyidahaliyatur strategiesforthesynthesisofbrevipolides |