A novel methodology for the efficient synthesis of 3-monohalooxindoles by acidolysis of 3-phosphate-substituted oxindoles with haloid acids

A novel method for the synthesis of 3-monohalooxindoles by acidolysis of isatin-derived 3-phosphate-substituted oxindoles with haloid acids was developed. This synthetic strategy involved the preparation of 3-phosphate-substituted oxindole intermediates and S(N)1 reactions with haloid acids. This ne...

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Autores principales: Liu, Li, Li, Yue, Huang, Tiao, Kong, Dulin, Wu, Mingshu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2021
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450974/
https://www.ncbi.nlm.nih.gov/pubmed/34621395
http://dx.doi.org/10.3762/bjoc.17.150
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author Liu, Li
Li, Yue
Huang, Tiao
Kong, Dulin
Wu, Mingshu
author_facet Liu, Li
Li, Yue
Huang, Tiao
Kong, Dulin
Wu, Mingshu
author_sort Liu, Li
collection PubMed
description A novel method for the synthesis of 3-monohalooxindoles by acidolysis of isatin-derived 3-phosphate-substituted oxindoles with haloid acids was developed. This synthetic strategy involved the preparation of 3-phosphate-substituted oxindole intermediates and S(N)1 reactions with haloid acids. This new procedure features mild reaction conditions, simple operation, good yield, readily available and inexpensive starting materials, and gram-scalability.
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spelling pubmed-84509742021-10-06 A novel methodology for the efficient synthesis of 3-monohalooxindoles by acidolysis of 3-phosphate-substituted oxindoles with haloid acids Liu, Li Li, Yue Huang, Tiao Kong, Dulin Wu, Mingshu Beilstein J Org Chem Full Research Paper A novel method for the synthesis of 3-monohalooxindoles by acidolysis of isatin-derived 3-phosphate-substituted oxindoles with haloid acids was developed. This synthetic strategy involved the preparation of 3-phosphate-substituted oxindole intermediates and S(N)1 reactions with haloid acids. This new procedure features mild reaction conditions, simple operation, good yield, readily available and inexpensive starting materials, and gram-scalability. Beilstein-Institut 2021-09-07 /pmc/articles/PMC8450974/ /pubmed/34621395 http://dx.doi.org/10.3762/bjoc.17.150 Text en Copyright © 2021, Liu et al. https://creativecommons.org/licenses/by/4.0/https://www.beilstein-journals.org/bjoc/terms/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ). Please note that the reuse, redistribution and reproduction in particular requires that the author(s) and source are credited and that individual graphics may be subject to special legal provisions. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms/terms)
spellingShingle Full Research Paper
Liu, Li
Li, Yue
Huang, Tiao
Kong, Dulin
Wu, Mingshu
A novel methodology for the efficient synthesis of 3-monohalooxindoles by acidolysis of 3-phosphate-substituted oxindoles with haloid acids
title A novel methodology for the efficient synthesis of 3-monohalooxindoles by acidolysis of 3-phosphate-substituted oxindoles with haloid acids
title_full A novel methodology for the efficient synthesis of 3-monohalooxindoles by acidolysis of 3-phosphate-substituted oxindoles with haloid acids
title_fullStr A novel methodology for the efficient synthesis of 3-monohalooxindoles by acidolysis of 3-phosphate-substituted oxindoles with haloid acids
title_full_unstemmed A novel methodology for the efficient synthesis of 3-monohalooxindoles by acidolysis of 3-phosphate-substituted oxindoles with haloid acids
title_short A novel methodology for the efficient synthesis of 3-monohalooxindoles by acidolysis of 3-phosphate-substituted oxindoles with haloid acids
title_sort novel methodology for the efficient synthesis of 3-monohalooxindoles by acidolysis of 3-phosphate-substituted oxindoles with haloid acids
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450974/
https://www.ncbi.nlm.nih.gov/pubmed/34621395
http://dx.doi.org/10.3762/bjoc.17.150
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