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The Potential of Metabolomic Analyses as Predictive Biomarkers of Preterm Delivery: A Systematic Review

SCOPE: as the leading cause of perinatal mortality and morbidity worldwide, the impact of premature delivery is undisputable. Thus far, non-invasive, cost-efficient and accurate biochemical markers to predict preterm delivery are scarce. The aim of this systematic review is to investigate the potent...

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Autores principales: Ronde, Emma, Reiss, Irwin K. M., Hankemeier, Thomas, De Meij, Tim G., Frerichs, Nina, Schoenmakers, Sam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451156/
https://www.ncbi.nlm.nih.gov/pubmed/34552554
http://dx.doi.org/10.3389/fendo.2021.668417
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author Ronde, Emma
Reiss, Irwin K. M.
Hankemeier, Thomas
De Meij, Tim G.
Frerichs, Nina
Schoenmakers, Sam
author_facet Ronde, Emma
Reiss, Irwin K. M.
Hankemeier, Thomas
De Meij, Tim G.
Frerichs, Nina
Schoenmakers, Sam
author_sort Ronde, Emma
collection PubMed
description SCOPE: as the leading cause of perinatal mortality and morbidity worldwide, the impact of premature delivery is undisputable. Thus far, non-invasive, cost-efficient and accurate biochemical markers to predict preterm delivery are scarce. The aim of this systematic review is to investigate the potential of non-invasive metabolomic biomarkers for the prediction of preterm delivery. METHODS AND RESULTS: Databases were systematically searched from March 2019 up to May 2020 resulting in 4062 articles, of which 45 were retrieved for full-text assessment. The resulting metabolites used for further analyses, such as ferritin, prostaglandin and different vitamins were obtained from different human anatomical compartments or sources (vaginal fluid, serum, urine and umbilical cord) and compared between groups of women with preterm and term delivery. None of the reported metabolites showed uniform results, however, a combination of metabolomics biomarkers may have potential to predict preterm delivery and need to be evaluated in future studies.
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spelling pubmed-84511562021-09-21 The Potential of Metabolomic Analyses as Predictive Biomarkers of Preterm Delivery: A Systematic Review Ronde, Emma Reiss, Irwin K. M. Hankemeier, Thomas De Meij, Tim G. Frerichs, Nina Schoenmakers, Sam Front Endocrinol (Lausanne) Endocrinology SCOPE: as the leading cause of perinatal mortality and morbidity worldwide, the impact of premature delivery is undisputable. Thus far, non-invasive, cost-efficient and accurate biochemical markers to predict preterm delivery are scarce. The aim of this systematic review is to investigate the potential of non-invasive metabolomic biomarkers for the prediction of preterm delivery. METHODS AND RESULTS: Databases were systematically searched from March 2019 up to May 2020 resulting in 4062 articles, of which 45 were retrieved for full-text assessment. The resulting metabolites used for further analyses, such as ferritin, prostaglandin and different vitamins were obtained from different human anatomical compartments or sources (vaginal fluid, serum, urine and umbilical cord) and compared between groups of women with preterm and term delivery. None of the reported metabolites showed uniform results, however, a combination of metabolomics biomarkers may have potential to predict preterm delivery and need to be evaluated in future studies. Frontiers Media S.A. 2021-09-06 /pmc/articles/PMC8451156/ /pubmed/34552554 http://dx.doi.org/10.3389/fendo.2021.668417 Text en Copyright © 2021 Ronde, Reiss, Hankemeier, De Meij, Frerichs and Schoenmakers https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Ronde, Emma
Reiss, Irwin K. M.
Hankemeier, Thomas
De Meij, Tim G.
Frerichs, Nina
Schoenmakers, Sam
The Potential of Metabolomic Analyses as Predictive Biomarkers of Preterm Delivery: A Systematic Review
title The Potential of Metabolomic Analyses as Predictive Biomarkers of Preterm Delivery: A Systematic Review
title_full The Potential of Metabolomic Analyses as Predictive Biomarkers of Preterm Delivery: A Systematic Review
title_fullStr The Potential of Metabolomic Analyses as Predictive Biomarkers of Preterm Delivery: A Systematic Review
title_full_unstemmed The Potential of Metabolomic Analyses as Predictive Biomarkers of Preterm Delivery: A Systematic Review
title_short The Potential of Metabolomic Analyses as Predictive Biomarkers of Preterm Delivery: A Systematic Review
title_sort potential of metabolomic analyses as predictive biomarkers of preterm delivery: a systematic review
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451156/
https://www.ncbi.nlm.nih.gov/pubmed/34552554
http://dx.doi.org/10.3389/fendo.2021.668417
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