Paradoxical Augmentation of Experimental Spondyloarthritis by RORC Inhibition in HLA-B27 Transgenic Rats

OBJECTIVE: IL-17A plays a major role in the pathogenesis of spondyloarthritis (SpA). Here we assessed the impact of inhibition of RAR related orphan receptor-γ (RORC), the key transcription factor controlling IL-17 production, on experimental SpA in HLA-B27 transgenic (tg) rats. METHODS: Experimenta...

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Detalles Bibliográficos
Autores principales: van Tok, Melissa N., Mandour, Mohamed, Wahle, Joseph, Labadia, Mark E., van de Sande, Marleen G. H., Nabozny, Gerald, Baeten, Dominique L., van Duivenvoorde, Leonie M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451327/
https://www.ncbi.nlm.nih.gov/pubmed/34552583
http://dx.doi.org/10.3389/fimmu.2021.699987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451327/
https://www.ncbi.nlm.nih.gov/pubmed/34552583
http://dx.doi.org/10.3389/fimmu.2021.699987

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