Cargando…

Digestive tract neoplasms in young individuals: Demographics, staging and risk factors

BACKGROUND: Digestive tract neoplasms (DTN) have become increasingly common worldwide among young individuals (YIs) over the last few decades. AIM: Aim of this research was to study the types, demographics, stage at presentation and risk factors of digestive tract neoplasms in young individuals. MET...

Descripción completa

Detalles Bibliográficos
Autores principales: Tasneem, Abbas Ali, Luck, Nasir Hassan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451370/
https://www.ncbi.nlm.nih.gov/pubmed/33295088
http://dx.doi.org/10.1002/cnr2.1319
_version_ 1784569830631800832
author Tasneem, Abbas Ali
Luck, Nasir Hassan
author_facet Tasneem, Abbas Ali
Luck, Nasir Hassan
author_sort Tasneem, Abbas Ali
collection PubMed
description BACKGROUND: Digestive tract neoplasms (DTN) have become increasingly common worldwide among young individuals (YIs) over the last few decades. AIM: Aim of this research was to study the types, demographics, stage at presentation and risk factors of digestive tract neoplasms in young individuals. METHODS AND RESULTS: In this cross‐sectional study, YI (ie, ≤40 years) presenting with any DTN including gastrointestinal neoplasms (GIN), hepatobiliary neoplasms (HBN), periampullary neoplasms (PAN) and others from June 2016 to May 2020 were included. Baseline laboratory tests, tissue diagnosis and staging were performed while risk factors were documented. A total of 163 patients were included in the study, of whom 82 (50.3%) were males. Mean age was 29.9 (±9.57) (range: 8 months‐40 years). Most DTN (93.3%; n = 152) were malignant. The commonest neoplasms were lower GIN (LGIN) 52 (31.9%), followed by HBN 46 (28.2%), upper GIN (UGIN) 44 (27%) and PAN 18 (11%). Commonest among LGIN were rectal 37; among HBN: hepatocellular cancer (HCC) 9, cholangiocarcinoma (CC) 9; and among UGIN: esophageal 25 and stomach 14. Rectal cancers were mostly sporadic (82.7%) with frequent signet ring cell histology (40.5%), and affected relatively younger ages compared to upper GIN and PAN. GIN were mostly locally advanced with higher resectability (LGIN 90.4%; UGIN 79.5%) while HBN were more advanced with lower resectability (HCC [44.4%]; CC [33.3%]). Poor dietary habits and poor socioeconomic status were common with UGIN (63.6%, 50%) and HBN (56.5%, 54.3%), respectively. CONCLUSION: The commonest DTN among YI were LGIN followed by HBN, UGIN and PAN. Rectal cancers affected relatively younger ages and were mostly sporadic. HBN were more advanced in stage and unresectable compared to GIN. Poor dietary habits and poor socioeconomic status may be important contributors in carcinogenesis.
format Online
Article
Text
id pubmed-8451370
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-84513702021-09-27 Digestive tract neoplasms in young individuals: Demographics, staging and risk factors Tasneem, Abbas Ali Luck, Nasir Hassan Cancer Rep (Hoboken) Original Articles BACKGROUND: Digestive tract neoplasms (DTN) have become increasingly common worldwide among young individuals (YIs) over the last few decades. AIM: Aim of this research was to study the types, demographics, stage at presentation and risk factors of digestive tract neoplasms in young individuals. METHODS AND RESULTS: In this cross‐sectional study, YI (ie, ≤40 years) presenting with any DTN including gastrointestinal neoplasms (GIN), hepatobiliary neoplasms (HBN), periampullary neoplasms (PAN) and others from June 2016 to May 2020 were included. Baseline laboratory tests, tissue diagnosis and staging were performed while risk factors were documented. A total of 163 patients were included in the study, of whom 82 (50.3%) were males. Mean age was 29.9 (±9.57) (range: 8 months‐40 years). Most DTN (93.3%; n = 152) were malignant. The commonest neoplasms were lower GIN (LGIN) 52 (31.9%), followed by HBN 46 (28.2%), upper GIN (UGIN) 44 (27%) and PAN 18 (11%). Commonest among LGIN were rectal 37; among HBN: hepatocellular cancer (HCC) 9, cholangiocarcinoma (CC) 9; and among UGIN: esophageal 25 and stomach 14. Rectal cancers were mostly sporadic (82.7%) with frequent signet ring cell histology (40.5%), and affected relatively younger ages compared to upper GIN and PAN. GIN were mostly locally advanced with higher resectability (LGIN 90.4%; UGIN 79.5%) while HBN were more advanced with lower resectability (HCC [44.4%]; CC [33.3%]). Poor dietary habits and poor socioeconomic status were common with UGIN (63.6%, 50%) and HBN (56.5%, 54.3%), respectively. CONCLUSION: The commonest DTN among YI were LGIN followed by HBN, UGIN and PAN. Rectal cancers affected relatively younger ages and were mostly sporadic. HBN were more advanced in stage and unresectable compared to GIN. Poor dietary habits and poor socioeconomic status may be important contributors in carcinogenesis. John Wiley and Sons Inc. 2020-12-09 /pmc/articles/PMC8451370/ /pubmed/33295088 http://dx.doi.org/10.1002/cnr2.1319 Text en © 2020 The Authors. Cancer Reports published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Tasneem, Abbas Ali
Luck, Nasir Hassan
Digestive tract neoplasms in young individuals: Demographics, staging and risk factors
title Digestive tract neoplasms in young individuals: Demographics, staging and risk factors
title_full Digestive tract neoplasms in young individuals: Demographics, staging and risk factors
title_fullStr Digestive tract neoplasms in young individuals: Demographics, staging and risk factors
title_full_unstemmed Digestive tract neoplasms in young individuals: Demographics, staging and risk factors
title_short Digestive tract neoplasms in young individuals: Demographics, staging and risk factors
title_sort digestive tract neoplasms in young individuals: demographics, staging and risk factors
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451370/
https://www.ncbi.nlm.nih.gov/pubmed/33295088
http://dx.doi.org/10.1002/cnr2.1319
work_keys_str_mv AT tasneemabbasali digestivetractneoplasmsinyoungindividualsdemographicsstagingandriskfactors
AT lucknasirhassan digestivetractneoplasmsinyoungindividualsdemographicsstagingandriskfactors