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Infrared light therapy relieves TLR-4 dependent hyper-inflammation of the type induced by COVID-19

The leading cause of mortality from COVID-19 infection is respiratory distress due to an exaggerated host immune response, resulting in hyper-inflammation and ensuing cytokine storms in the lungs. Current drug-based therapies are of limited efficacy, costly, and have potential negative side effects....

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Autores principales: Aguida, Blanche, Pooam, Marootpong, Ahmad, Margaret, Jourdan, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451450/
https://www.ncbi.nlm.nih.gov/pubmed/34552685
http://dx.doi.org/10.1080/19420889.2021.1965718
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author Aguida, Blanche
Pooam, Marootpong
Ahmad, Margaret
Jourdan, Nathalie
author_facet Aguida, Blanche
Pooam, Marootpong
Ahmad, Margaret
Jourdan, Nathalie
author_sort Aguida, Blanche
collection PubMed
description The leading cause of mortality from COVID-19 infection is respiratory distress due to an exaggerated host immune response, resulting in hyper-inflammation and ensuing cytokine storms in the lungs. Current drug-based therapies are of limited efficacy, costly, and have potential negative side effects. By contrast, photobiomodulation therapy, which involves periodic brief exposure to red or infrared light, is a noninvasive, safe, and affordable method that is currently being used to treat a wide range of diseases with underlying inflammatory conditions. Here, we show that exposure to two 10-min, high-intensity periods per day of infrared light causes a marked reduction in the TLR-4 dependent inflammatory response pathway, which has been implicated in the onset of cytokine storms in COVID-19 patients. Infrared light exposure resulted in a significant decline in NFkB and AP1 activity as measured by the reporter gene assay; decreased expression of inflammatory marker genes IL-6, IL-8, TNF-alpha, INF-alpha, and INF-beta as determined by qPCR gene expression assay; and an 80% decline in secreted cytokine IL6 as measured by ELISA assay in cultured human cells. All of these changes occurred after only 48 hours of treatment. We suggest that an underlying cellular mechanism involving modulation of ROS may downregulate the host immune response after Infrared Light exposure, leading to decrease in inflammation. We further discuss technical considerations involving light sources and exposure conditions to put these observations into potential clinical use to treat COVID-19 induced mortality.
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spelling pubmed-84514502021-09-21 Infrared light therapy relieves TLR-4 dependent hyper-inflammation of the type induced by COVID-19 Aguida, Blanche Pooam, Marootpong Ahmad, Margaret Jourdan, Nathalie Commun Integr Biol Short Communication The leading cause of mortality from COVID-19 infection is respiratory distress due to an exaggerated host immune response, resulting in hyper-inflammation and ensuing cytokine storms in the lungs. Current drug-based therapies are of limited efficacy, costly, and have potential negative side effects. By contrast, photobiomodulation therapy, which involves periodic brief exposure to red or infrared light, is a noninvasive, safe, and affordable method that is currently being used to treat a wide range of diseases with underlying inflammatory conditions. Here, we show that exposure to two 10-min, high-intensity periods per day of infrared light causes a marked reduction in the TLR-4 dependent inflammatory response pathway, which has been implicated in the onset of cytokine storms in COVID-19 patients. Infrared light exposure resulted in a significant decline in NFkB and AP1 activity as measured by the reporter gene assay; decreased expression of inflammatory marker genes IL-6, IL-8, TNF-alpha, INF-alpha, and INF-beta as determined by qPCR gene expression assay; and an 80% decline in secreted cytokine IL6 as measured by ELISA assay in cultured human cells. All of these changes occurred after only 48 hours of treatment. We suggest that an underlying cellular mechanism involving modulation of ROS may downregulate the host immune response after Infrared Light exposure, leading to decrease in inflammation. We further discuss technical considerations involving light sources and exposure conditions to put these observations into potential clinical use to treat COVID-19 induced mortality. Taylor & Francis 2021-09-15 /pmc/articles/PMC8451450/ /pubmed/34552685 http://dx.doi.org/10.1080/19420889.2021.1965718 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Aguida, Blanche
Pooam, Marootpong
Ahmad, Margaret
Jourdan, Nathalie
Infrared light therapy relieves TLR-4 dependent hyper-inflammation of the type induced by COVID-19
title Infrared light therapy relieves TLR-4 dependent hyper-inflammation of the type induced by COVID-19
title_full Infrared light therapy relieves TLR-4 dependent hyper-inflammation of the type induced by COVID-19
title_fullStr Infrared light therapy relieves TLR-4 dependent hyper-inflammation of the type induced by COVID-19
title_full_unstemmed Infrared light therapy relieves TLR-4 dependent hyper-inflammation of the type induced by COVID-19
title_short Infrared light therapy relieves TLR-4 dependent hyper-inflammation of the type induced by COVID-19
title_sort infrared light therapy relieves tlr-4 dependent hyper-inflammation of the type induced by covid-19
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451450/
https://www.ncbi.nlm.nih.gov/pubmed/34552685
http://dx.doi.org/10.1080/19420889.2021.1965718
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