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Serum amyloid P component: a new biomarker for low sperm concentration?
Serum amyloid P component (SAP) is present in seminal plasma, on spermatozoa, and in different tissues of the male reproductive tract, but its function is not known. The aims of this study were to determine if the concentration of SAP in seminal plasma is associated with commonly assessed semen para...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451485/ https://www.ncbi.nlm.nih.gov/pubmed/33723096 http://dx.doi.org/10.4103/aja.aja_7_21 |
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author | Sonesson, Annika Malm, Johan Rylander, Lars Giwercman, Aleksander Hillarp, Andreas |
author_facet | Sonesson, Annika Malm, Johan Rylander, Lars Giwercman, Aleksander Hillarp, Andreas |
author_sort | Sonesson, Annika |
collection | PubMed |
description | Serum amyloid P component (SAP) is present in seminal plasma, on spermatozoa, and in different tissues of the male reproductive tract, but its function is not known. The aims of this study were to determine if the concentration of SAP in seminal plasma is associated with commonly assessed semen parameters and to investigate if SAP could be a new, indirect biomarker for these parameters. In a cross-sectional study of 203 young volunteers, the concentration of SAP in seminal plasma was measured with a in-house developed enzyme-linked immunosorbent assay. Scatter plots, Pearson's correlation coefficients (r), and linear regression models were produced, and SAP showed a statistically significant correlation with sperm concentration (r = 0.75), sperm number (r = 0.68), semen volume (r = −0.19), progressive sperm motility (r = 0.24), and sperm immotility (r = −0.20). When the study group was dichotomized, SAP could be used to discriminate samples with a sperm concentration < or ≥5 × 10(6) ml(−1), 15 × 10(6) ml(−1), or 40 × 10(6) ml(−1), and in receiver operating characteristic curves, the corresponding areas under the curves were 0.97, 0.93, and 0.82, respectively, with P < 0.001 for all three cutoff values studied. The concentration of SAP in seminal plasma showed a strong, positive correlation with the concentration of spermatozoa in semen. SAP may be used as a new indirect potential biomarker for sperm concentration in fresh and in frozen, stored samples. In addition, it is envisaged that the assay could be developed into a home fertility test to differentiate between a low and a normal sperm concentration. |
format | Online Article Text |
id | pubmed-8451485 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-84514852021-10-18 Serum amyloid P component: a new biomarker for low sperm concentration? Sonesson, Annika Malm, Johan Rylander, Lars Giwercman, Aleksander Hillarp, Andreas Asian J Androl Original Article Serum amyloid P component (SAP) is present in seminal plasma, on spermatozoa, and in different tissues of the male reproductive tract, but its function is not known. The aims of this study were to determine if the concentration of SAP in seminal plasma is associated with commonly assessed semen parameters and to investigate if SAP could be a new, indirect biomarker for these parameters. In a cross-sectional study of 203 young volunteers, the concentration of SAP in seminal plasma was measured with a in-house developed enzyme-linked immunosorbent assay. Scatter plots, Pearson's correlation coefficients (r), and linear regression models were produced, and SAP showed a statistically significant correlation with sperm concentration (r = 0.75), sperm number (r = 0.68), semen volume (r = −0.19), progressive sperm motility (r = 0.24), and sperm immotility (r = −0.20). When the study group was dichotomized, SAP could be used to discriminate samples with a sperm concentration < or ≥5 × 10(6) ml(−1), 15 × 10(6) ml(−1), or 40 × 10(6) ml(−1), and in receiver operating characteristic curves, the corresponding areas under the curves were 0.97, 0.93, and 0.82, respectively, with P < 0.001 for all three cutoff values studied. The concentration of SAP in seminal plasma showed a strong, positive correlation with the concentration of spermatozoa in semen. SAP may be used as a new indirect potential biomarker for sperm concentration in fresh and in frozen, stored samples. In addition, it is envisaged that the assay could be developed into a home fertility test to differentiate between a low and a normal sperm concentration. Wolters Kluwer - Medknow 2021-03-12 /pmc/articles/PMC8451485/ /pubmed/33723096 http://dx.doi.org/10.4103/aja.aja_7_21 Text en Copyright: ©The Author(s)(2021) https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Sonesson, Annika Malm, Johan Rylander, Lars Giwercman, Aleksander Hillarp, Andreas Serum amyloid P component: a new biomarker for low sperm concentration? |
title | Serum amyloid P component: a new biomarker for low sperm concentration? |
title_full | Serum amyloid P component: a new biomarker for low sperm concentration? |
title_fullStr | Serum amyloid P component: a new biomarker for low sperm concentration? |
title_full_unstemmed | Serum amyloid P component: a new biomarker for low sperm concentration? |
title_short | Serum amyloid P component: a new biomarker for low sperm concentration? |
title_sort | serum amyloid p component: a new biomarker for low sperm concentration? |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451485/ https://www.ncbi.nlm.nih.gov/pubmed/33723096 http://dx.doi.org/10.4103/aja.aja_7_21 |
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