Cargando…

Neural stem cell transplantation alleviates functional cognitive deficits in a mouse model of tauopathy

The mechanisms of the transplantation of neural stem cells (NSCs) in the treatment of Alzheimer’s disease remain poorly understood. In this study, NSCs were transplanted into the hippocampal CA1 region of the rTg (tau P301L) 4510 mouse model, a tauopathy model that is thought to reflect the tau path...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, He-Ao, Yuan, Chun-Xu, Liu, Ke-Fu, Yang, Qi-Fan, Zhao, Juan, Li, Hui, Yang, Qing-Hu, Song, Da, Quan, Zhen-Zhen, Qing, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer - Medknow 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451553/ https://www.ncbi.nlm.nih.gov/pubmed/34100451 http://dx.doi.org/10.4103/1673-5374.314324

Ejemplares similares

Epigenetic treatment of behavioral and physiological deficits in a tauopathy mouse model
por: Wang, Wei, et al.
Publicado: (2021)

Inhibition of histone methyltransferase Smyd3 rescues NMDAR and cognitive deficits in a tauopathy mouse model
por: Williams, Jamal B., et al.
Publicado: (2023)

Early Cognitive and Behavioral Deficits in Mouse Models for Tauopathy and Alzheimer’s Disease
por: Samaey, Celine, et al.
Publicado: (2019)

PINK1 Alleviates Cognitive Impairments via Attenuating Pathological Tau Aggregation in a Mouse Model of Tauopathy
por: Jiang, Xing Jun, et al.
Publicado: (2022)

Longitudinal characterization of behavioral, morphological and transcriptomic changes in a tauopathy mouse model
por: Cao, Qing, et al.
Publicado: (2023)

Scutellarin may alleviate cognitive deficits in a mouse model of hypoxia by promoting proliferation and neuronal differentiation of neural stem cells
por: Wang, Wei-Wei, et al.
Publicado: (2017)

Tetrandrine ameliorates cognitive deficits and mitigates tau aggregation in cell and animal models of tauopathies
por: Tong, Benjamin Chun-Kit, et al.
Publicado: (2022)

Astrocytes in mouse models of tauopathies acquire early deficits and lose neurosupportive functions
por: Sidoryk-Wegrzynowicz, Marta, et al.
Publicado: (2017)

Intracerebral Transplantation of Neural Stem Cells Restores Manganese-Induced Cognitive Deficits in Mice
por: Shu, Huijuan, et al.
Publicado: (2021)

Glucose deficit triggers tau pathology and synaptic dysfunction in a tauopathy mouse model
por: Lauretti, E, et al.
Publicado: (2017)

NITRIC OXIDE SYNTHASE DYSFUNCTION UNDERLIES CEREBROVASCULAR DEFICITS IN A MOUSE MODEL OF TAUOPATHY
por: Van Skike, Candice E, et al.
Publicado: (2019)

Targeting histone K4 trimethylation for treatment of cognitive and synaptic deficits in mouse models of Alzheimer’s disease
por: Cao, Qing, et al.
Publicado: (2020)

Targeted Reducing of Tauopathy Alleviates Epileptic Seizures and Spatial Memory Impairment in an Optogenetically Inducible Mouse Model of Epilepsy
por: Gao, Yang, et al.
Publicado: (2021)

Trilobatin Alleviates Cognitive Deficits and Pathologies in an Alzheimer's Disease Mouse Model
por: Ding, Jiuyang, et al.
Publicado: (2021)

Neuropathological changes and cognitive deficits in rats transgenic for human mutant tau recapitulate human tauopathy
por: Malcolm, Janice C., et al.
Publicado: (2019)

Caffeine Consumption During Pregnancy Accelerates the Development of Cognitive Deficits in Offspring in a Model of Tauopathy
por: Zappettini, Stefania, et al.
Publicado: (2019)

The overexpression of RBM3 alleviates TBI‐induced behaviour impairment and AD‐like tauopathy in mice
por: Liu, Bingjin, et al.
Publicado: (2020)

Erythropoietin-derived peptide treatment reduced neurological deficit and neuropathological changes in a mouse model of tauopathy
por: Choi, Yun-Beom, et al.
Publicado: (2021)

Chronic Sodium Selenate Treatment Restores Deficits in Cognition and Synaptic Plasticity in a Murine Model of Tauopathy
por: Ahmed, Tariq, et al.
Publicado: (2020)

Passive Immunization with Phospho-Tau Antibodies Reduces Tau Pathology and Functional Deficits in Two Distinct Mouse Tauopathy Models
por: Sankaranarayanan, Sethu, et al.
Publicado: (2015)

Mutant β(1)-adrenergic receptor improves REM sleep and ameliorates tau accumulation in a mouse model of tauopathy
por: Dong, Qing, et al.
Publicado: (2023)

Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy
por: Laurent, Cyril, et al.
Publicado: (2017)

Dihuang-Yinzi Alleviates Cognition Deficits via Targeting Energy-Related Metabolism in an Alzheimer Mouse Model as Demonstrated by Integration of Metabolomics and Network Pharmacology
por: Han, Guanghui, et al.
Publicado: (2022)

Transplantation of Induced Pluripotent Stem Cells Alleviates Cerebral Inflammation and Neural Damage in Hemorrhagic Stroke
por: Qin, Jie, et al.
Publicado: (2015)

Transmission and spreading of tauopathy in transgenic mouse brain
por: Clavaguera, Florence, et al.
Publicado: (2009)

Human Neural Stem Cells Reinforce Hippocampal Synaptic Network and Rescue Cognitive Deficits in a Mouse Model of Alzheimer's Disease
por: Zhang, Ting, et al.
Publicado: (2019)

The Neural Correlates of Effortful Cognitive Processing Deficits in Schizophrenia: An ERP Study
por: Jiang, Chen-Guang, et al.
Publicado: (2021)

Novel autoimmune response in a tauopathy mouse model
por: Nogueras-Ortiz, Carlos J., et al.
Publicado: (2014)

Using mass spectrometry to validate mouse models of tauopathy
por: Yan, Yan, et al.
Publicado: (2023)

Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model
por: Shi, Yang, et al.
Publicado: (2019)

The direct role of 5-lipoxygenase on tau pathology, synaptic integrity and cognition in a mouse model of tauopathy
por: Vagnozzi, Alana N., et al.
Publicado: (2017)

Astrocytes in Tauopathies
por: Reid, Matthew J., et al.
Publicado: (2020)

A single systemic inflammatory insult causes acute motor deficits and accelerates disease progression in a mouse model of human tauopathy
por: Torvell, Megan, et al.
Publicado: (2019)

NLRP3/Caspase-1 Pathway-Induced Pyroptosis Mediated Cognitive Deficits in a Mouse Model of Sepsis-Associated Encephalopathy
por: Fu, Qun, et al.
Publicado: (2018)

Anti-Inflammatory Impact of Minocycline in a Mouse Model of Tauopathy
por: Garwood, Claire J., et al.
Publicado: (2010)

Analysis of in vivo turnover of tau in a mouse model of tauopathy
por: Yamada, Kaoru, et al.
Publicado: (2015)

Early alterations of neurovascular unit in the retina in mouse models of tauopathy
por: Xia, Fan, et al.
Publicado: (2021)

Plasticity in visual cortex is disrupted in a mouse model of tauopathy
por: Papanikolaou, Amalia, et al.
Publicado: (2022)

Tauopathies: new perspectives and challenges
por: Zhang, Yi, et al.
Publicado: (2022)

Transcriptomic analysis of human brains with Alzheimer’s disease reveals the altered expression of synaptic genes linked to cognitive deficits
por: Williams, Jamal B, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_bv2nje6lh8jiipsjsl89m391b4