Research advances on how metformin improves memory impairment in “chemobrain”

Cognitive impairment caused by chemotherapy, referred to as “chemobrain,” is observed in approximately 70% of cancer survivors. However, it is not completely understood how chemotherapy induces cognitive dysfunction, and clinical treatment strategies for this problem are lacking. Metformin, used as...

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Detalles Bibliográficos
Autores principales: Alhowail, Ahmad, Chigurupati, Sridevi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451574/
https://www.ncbi.nlm.nih.gov/pubmed/34100420
http://dx.doi.org/10.4103/1673-5374.314284
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author Alhowail, Ahmad
Chigurupati, Sridevi
author_facet Alhowail, Ahmad
Chigurupati, Sridevi
author_sort Alhowail, Ahmad
collection PubMed
description Cognitive impairment caused by chemotherapy, referred to as “chemobrain,” is observed in approximately 70% of cancer survivors. However, it is not completely understood how chemotherapy induces cognitive dysfunction, and clinical treatment strategies for this problem are lacking. Metformin, used as a first-line treatment for type 2 diabetes mellitus, is reported to reduce the effects of chemobrain. Recently, several studies have examined the effect of metformin in rescuing chemobrain. This review discusses recent clinical/preclinical studies that addressed some mechanisms of chemobrain and evaluates the effect of metformin in rescuing chemobrain and its potential mechanisms of action.
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spelling pubmed-84515742021-10-18 Research advances on how metformin improves memory impairment in “chemobrain” Alhowail, Ahmad Chigurupati, Sridevi Neural Regen Res Review Cognitive impairment caused by chemotherapy, referred to as “chemobrain,” is observed in approximately 70% of cancer survivors. However, it is not completely understood how chemotherapy induces cognitive dysfunction, and clinical treatment strategies for this problem are lacking. Metformin, used as a first-line treatment for type 2 diabetes mellitus, is reported to reduce the effects of chemobrain. Recently, several studies have examined the effect of metformin in rescuing chemobrain. This review discusses recent clinical/preclinical studies that addressed some mechanisms of chemobrain and evaluates the effect of metformin in rescuing chemobrain and its potential mechanisms of action. Wolters Kluwer - Medknow 2021-06-07 /pmc/articles/PMC8451574/ /pubmed/34100420 http://dx.doi.org/10.4103/1673-5374.314284 Text en Copyright: © Neural Regeneration Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review
Alhowail, Ahmad
Chigurupati, Sridevi
Research advances on how metformin improves memory impairment in “chemobrain”
title Research advances on how metformin improves memory impairment in “chemobrain”
title_full Research advances on how metformin improves memory impairment in “chemobrain”
title_fullStr Research advances on how metformin improves memory impairment in “chemobrain”
title_full_unstemmed Research advances on how metformin improves memory impairment in “chemobrain”
title_short Research advances on how metformin improves memory impairment in “chemobrain”
title_sort research advances on how metformin improves memory impairment in “chemobrain”
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451574/
https://www.ncbi.nlm.nih.gov/pubmed/34100420
http://dx.doi.org/10.4103/1673-5374.314284
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