Rational formulation engineering of fraxinellone utilizing 6-O-α-D-maltosyl-β-cyclodextrin for enhanced oral bioavailability and hepatic fibrosis therapy

Although Fraxinellone (Frax) isolated from Dictamnus albus L. possessed excellent anti-hepatic fibrosis activity, oral administration of Frax suffered from the inefficient therapeutic outcome in vivo due to negligible oral absorption. At present, the oral formulation of Frax is rarely exploited. For...

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Detalles Bibliográficos
Autores principales: Li, Jianbo, Feng, Tiange, Yang, Weijing, Xu, Yaru, Wang, Shuaishuai, Cai, Huijie, Liu, Zhilei, Qiang, Hong, Zhang, Jinjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451604/
https://www.ncbi.nlm.nih.gov/pubmed/34519225
http://dx.doi.org/10.1080/10717544.2021.1976310

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451604/
https://www.ncbi.nlm.nih.gov/pubmed/34519225
http://dx.doi.org/10.1080/10717544.2021.1976310

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