Cargando…

High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study

Male sex was repeatedly identified as a risk factor for death and intensive care admission. However, it is yet unclear whether sex hormones are associated with disease severity in COVID-19 patients. In this study, we analysed sex hormone levels (estradiol and testosterone) of male and female COVID-1...

Descripción completa

Detalles Bibliográficos
Autores principales: Schroeder, Maria, Schaumburg, Berfin, Mueller, Zacharias, Parplys, Ann, Jarczak, Dominik, Roedl, Kevin, Nierhaus, Axel, de Heer, Geraldine, Grensemann, Joern, Schneider, Bettina, Stoll, Fabian, Bai, Tian, Jacobsen, Henning, Zickler, Martin, Stanelle-Bertram, Stephanie, Klaetschke, Kristin, Renné, Thomas, Meinhardt, Andreas, Aberle, Jens, Hiller, Jens, Peine, Sven, Kreienbrock, Lothar, Klingel, Karin, Kluge, Stefan, Gabriel, Guelsah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451658/
https://www.ncbi.nlm.nih.gov/pubmed/34402750
http://dx.doi.org/10.1080/22221751.2021.1969869
_version_ 1784569893542166528
author Schroeder, Maria
Schaumburg, Berfin
Mueller, Zacharias
Parplys, Ann
Jarczak, Dominik
Roedl, Kevin
Nierhaus, Axel
de Heer, Geraldine
Grensemann, Joern
Schneider, Bettina
Stoll, Fabian
Bai, Tian
Jacobsen, Henning
Zickler, Martin
Stanelle-Bertram, Stephanie
Klaetschke, Kristin
Renné, Thomas
Meinhardt, Andreas
Aberle, Jens
Hiller, Jens
Peine, Sven
Kreienbrock, Lothar
Klingel, Karin
Kluge, Stefan
Gabriel, Guelsah
author_facet Schroeder, Maria
Schaumburg, Berfin
Mueller, Zacharias
Parplys, Ann
Jarczak, Dominik
Roedl, Kevin
Nierhaus, Axel
de Heer, Geraldine
Grensemann, Joern
Schneider, Bettina
Stoll, Fabian
Bai, Tian
Jacobsen, Henning
Zickler, Martin
Stanelle-Bertram, Stephanie
Klaetschke, Kristin
Renné, Thomas
Meinhardt, Andreas
Aberle, Jens
Hiller, Jens
Peine, Sven
Kreienbrock, Lothar
Klingel, Karin
Kluge, Stefan
Gabriel, Guelsah
author_sort Schroeder, Maria
collection PubMed
description Male sex was repeatedly identified as a risk factor for death and intensive care admission. However, it is yet unclear whether sex hormones are associated with disease severity in COVID-19 patients. In this study, we analysed sex hormone levels (estradiol and testosterone) of male and female COVID-19 patients (n = 50) admitted to an intensive care unit (ICU) in comparison to control non-COVID-19 patients at the ICU (n = 42), non-COVID-19 patients with the most prevalent comorbidity (coronary heart diseases) present within the COVID-19 cohort (n = 39) and healthy individuals (n = 50). We detected significantly elevated estradiol levels in critically ill male COVID-19 patients compared to all control cohorts. Testosterone levels were significantly reduced in critically ill male COVID-19 patients compared to control cohorts. No statistically significant differences in sex hormone levels were detected in critically ill female COVID-19 patients, albeit similar trends towards elevated estradiol levels were observed. Linear regression analysis revealed that among a broad range of cytokines and chemokines analysed, IFN-γ levels are positively associated with estradiol levels in male and female COVID-19 patients. Furthermore, male COVID-19 patients with elevated estradiol levels were more likely to receive ECMO treatment. Thus, we herein identified that disturbance of sex hormone metabolism might present a hallmark in critically ill male COVID-19 patients.
format Online
Article
Text
id pubmed-8451658
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-84516582021-09-21 High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study Schroeder, Maria Schaumburg, Berfin Mueller, Zacharias Parplys, Ann Jarczak, Dominik Roedl, Kevin Nierhaus, Axel de Heer, Geraldine Grensemann, Joern Schneider, Bettina Stoll, Fabian Bai, Tian Jacobsen, Henning Zickler, Martin Stanelle-Bertram, Stephanie Klaetschke, Kristin Renné, Thomas Meinhardt, Andreas Aberle, Jens Hiller, Jens Peine, Sven Kreienbrock, Lothar Klingel, Karin Kluge, Stefan Gabriel, Guelsah Emerg Microbes Infect Original Article Male sex was repeatedly identified as a risk factor for death and intensive care admission. However, it is yet unclear whether sex hormones are associated with disease severity in COVID-19 patients. In this study, we analysed sex hormone levels (estradiol and testosterone) of male and female COVID-19 patients (n = 50) admitted to an intensive care unit (ICU) in comparison to control non-COVID-19 patients at the ICU (n = 42), non-COVID-19 patients with the most prevalent comorbidity (coronary heart diseases) present within the COVID-19 cohort (n = 39) and healthy individuals (n = 50). We detected significantly elevated estradiol levels in critically ill male COVID-19 patients compared to all control cohorts. Testosterone levels were significantly reduced in critically ill male COVID-19 patients compared to control cohorts. No statistically significant differences in sex hormone levels were detected in critically ill female COVID-19 patients, albeit similar trends towards elevated estradiol levels were observed. Linear regression analysis revealed that among a broad range of cytokines and chemokines analysed, IFN-γ levels are positively associated with estradiol levels in male and female COVID-19 patients. Furthermore, male COVID-19 patients with elevated estradiol levels were more likely to receive ECMO treatment. Thus, we herein identified that disturbance of sex hormone metabolism might present a hallmark in critically ill male COVID-19 patients. Taylor & Francis 2021-09-14 /pmc/articles/PMC8451658/ /pubmed/34402750 http://dx.doi.org/10.1080/22221751.2021.1969869 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Schroeder, Maria
Schaumburg, Berfin
Mueller, Zacharias
Parplys, Ann
Jarczak, Dominik
Roedl, Kevin
Nierhaus, Axel
de Heer, Geraldine
Grensemann, Joern
Schneider, Bettina
Stoll, Fabian
Bai, Tian
Jacobsen, Henning
Zickler, Martin
Stanelle-Bertram, Stephanie
Klaetschke, Kristin
Renné, Thomas
Meinhardt, Andreas
Aberle, Jens
Hiller, Jens
Peine, Sven
Kreienbrock, Lothar
Klingel, Karin
Kluge, Stefan
Gabriel, Guelsah
High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study
title High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study
title_full High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study
title_fullStr High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study
title_full_unstemmed High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study
title_short High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study
title_sort high estradiol and low testosterone levels are associated with critical illness in male but not in female covid-19 patients: a retrospective cohort study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451658/
https://www.ncbi.nlm.nih.gov/pubmed/34402750
http://dx.doi.org/10.1080/22221751.2021.1969869
work_keys_str_mv AT schroedermaria highestradiolandlowtestosteronelevelsareassociatedwithcriticalillnessinmalebutnotinfemalecovid19patientsaretrospectivecohortstudy
AT schaumburgberfin highestradiolandlowtestosteronelevelsareassociatedwithcriticalillnessinmalebutnotinfemalecovid19patientsaretrospectivecohortstudy
AT muellerzacharias highestradiolandlowtestosteronelevelsareassociatedwithcriticalillnessinmalebutnotinfemalecovid19patientsaretrospectivecohortstudy
AT parplysann highestradiolandlowtestosteronelevelsareassociatedwithcriticalillnessinmalebutnotinfemalecovid19patientsaretrospectivecohortstudy
AT jarczakdominik highestradiolandlowtestosteronelevelsareassociatedwithcriticalillnessinmalebutnotinfemalecovid19patientsaretrospectivecohortstudy
AT roedlkevin highestradiolandlowtestosteronelevelsareassociatedwithcriticalillnessinmalebutnotinfemalecovid19patientsaretrospectivecohortstudy
AT nierhausaxel highestradiolandlowtestosteronelevelsareassociatedwithcriticalillnessinmalebutnotinfemalecovid19patientsaretrospectivecohortstudy
AT deheergeraldine highestradiolandlowtestosteronelevelsareassociatedwithcriticalillnessinmalebutnotinfemalecovid19patientsaretrospectivecohortstudy
AT grensemannjoern highestradiolandlowtestosteronelevelsareassociatedwithcriticalillnessinmalebutnotinfemalecovid19patientsaretrospectivecohortstudy
AT schneiderbettina highestradiolandlowtestosteronelevelsareassociatedwithcriticalillnessinmalebutnotinfemalecovid19patientsaretrospectivecohortstudy
AT stollfabian highestradiolandlowtestosteronelevelsareassociatedwithcriticalillnessinmalebutnotinfemalecovid19patientsaretrospectivecohortstudy
AT baitian highestradiolandlowtestosteronelevelsareassociatedwithcriticalillnessinmalebutnotinfemalecovid19patientsaretrospectivecohortstudy
AT jacobsenhenning highestradiolandlowtestosteronelevelsareassociatedwithcriticalillnessinmalebutnotinfemalecovid19patientsaretrospectivecohortstudy
AT zicklermartin highestradiolandlowtestosteronelevelsareassociatedwithcriticalillnessinmalebutnotinfemalecovid19patientsaretrospectivecohortstudy
AT stanellebertramstephanie highestradiolandlowtestosteronelevelsareassociatedwithcriticalillnessinmalebutnotinfemalecovid19patientsaretrospectivecohortstudy
AT klaetschkekristin highestradiolandlowtestosteronelevelsareassociatedwithcriticalillnessinmalebutnotinfemalecovid19patientsaretrospectivecohortstudy
AT rennethomas highestradiolandlowtestosteronelevelsareassociatedwithcriticalillnessinmalebutnotinfemalecovid19patientsaretrospectivecohortstudy
AT meinhardtandreas highestradiolandlowtestosteronelevelsareassociatedwithcriticalillnessinmalebutnotinfemalecovid19patientsaretrospectivecohortstudy
AT aberlejens highestradiolandlowtestosteronelevelsareassociatedwithcriticalillnessinmalebutnotinfemalecovid19patientsaretrospectivecohortstudy
AT hillerjens highestradiolandlowtestosteronelevelsareassociatedwithcriticalillnessinmalebutnotinfemalecovid19patientsaretrospectivecohortstudy
AT peinesven highestradiolandlowtestosteronelevelsareassociatedwithcriticalillnessinmalebutnotinfemalecovid19patientsaretrospectivecohortstudy
AT kreienbrocklothar highestradiolandlowtestosteronelevelsareassociatedwithcriticalillnessinmalebutnotinfemalecovid19patientsaretrospectivecohortstudy
AT klingelkarin highestradiolandlowtestosteronelevelsareassociatedwithcriticalillnessinmalebutnotinfemalecovid19patientsaretrospectivecohortstudy
AT klugestefan highestradiolandlowtestosteronelevelsareassociatedwithcriticalillnessinmalebutnotinfemalecovid19patientsaretrospectivecohortstudy
AT gabrielguelsah highestradiolandlowtestosteronelevelsareassociatedwithcriticalillnessinmalebutnotinfemalecovid19patientsaretrospectivecohortstudy