Rational design of a deuterium-containing M2-S31N channel blocker UAWJ280 with in vivo antiviral efficacy against both oseltamivir sensitive and -resistant influenza A viruses

Seasonal influenza A virus (IAV) infections are among the most important global health problems. FDA-approved antiviral therapies against IAV include neuraminidase inhibitors, M2 inhibitors, and polymerase inhibitor baloxavir. Resistance against adamantanes (amantadine and rimantadine) is widespread...

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Detalles Bibliográficos
Autores principales: Cáceres, C. Joaquín, Hu, Yanmei, Cárdenas-García, Stivalis, Wu, Xiangmeng, Tan, Haozhou, Carnaccini, Silvia, Gay, L. Claire, Geiger, Ginger, Ma, Chunlong, Zhang, Qing-Yu, Rajao, Daniela, Perez, Daniel R., Wang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451667/
https://www.ncbi.nlm.nih.gov/pubmed/34427541
http://dx.doi.org/10.1080/22221751.2021.1972769

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