Immature granulocytes can help the diagnosis of pulmonary bacterial infections in patients with severe COVID-19 pneumonia

During COVID-19, immature granulocyte (IG) concentration is heterogeneous with higher concentrations than those found in bacterial sepsis. We investigated the relationship between IG levels at ICU admission and on days 7 (± 2) and 15 (± 2) and associated pulmonary bacterial infections in intensive c...

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Autores principales: Daix, Thomas, Jeannet, Robin, Hernandez Padilla, Ana Catalina, Vignon, Philippe, Feuillard, Jean, François, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451732/
https://www.ncbi.nlm.nih.gov/pubmed/34544474
http://dx.doi.org/10.1186/s40560-021-00575-3
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author Daix, Thomas
Jeannet, Robin
Hernandez Padilla, Ana Catalina
Vignon, Philippe
Feuillard, Jean
François, Bruno
author_facet Daix, Thomas
Jeannet, Robin
Hernandez Padilla, Ana Catalina
Vignon, Philippe
Feuillard, Jean
François, Bruno
author_sort Daix, Thomas
collection PubMed
description During COVID-19, immature granulocyte (IG) concentration is heterogeneous with higher concentrations than those found in bacterial sepsis. We investigated the relationship between IG levels at ICU admission and on days 7 (± 2) and 15 (± 2) and associated pulmonary bacterial infections in intensive care unit (ICU) patients hospitalized for an acute respiratory distress syndrome (ARDS) related to SARS-CoV-2. Patients with associated pulmonary bacterial infection had a peak of IGs. IG thresholds of 18% or 2 G/L allowed discriminating patients with ventilator associated pneumonia with 100% sensitivity and specificity. Our study supports that IGs could help identifying pulmonary bacterial infections in this population. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40560-021-00575-3.
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spelling pubmed-84517322021-09-21 Immature granulocytes can help the diagnosis of pulmonary bacterial infections in patients with severe COVID-19 pneumonia Daix, Thomas Jeannet, Robin Hernandez Padilla, Ana Catalina Vignon, Philippe Feuillard, Jean François, Bruno J Intensive Care Letter to the Editor During COVID-19, immature granulocyte (IG) concentration is heterogeneous with higher concentrations than those found in bacterial sepsis. We investigated the relationship between IG levels at ICU admission and on days 7 (± 2) and 15 (± 2) and associated pulmonary bacterial infections in intensive care unit (ICU) patients hospitalized for an acute respiratory distress syndrome (ARDS) related to SARS-CoV-2. Patients with associated pulmonary bacterial infection had a peak of IGs. IG thresholds of 18% or 2 G/L allowed discriminating patients with ventilator associated pneumonia with 100% sensitivity and specificity. Our study supports that IGs could help identifying pulmonary bacterial infections in this population. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40560-021-00575-3. BioMed Central 2021-09-20 /pmc/articles/PMC8451732/ /pubmed/34544474 http://dx.doi.org/10.1186/s40560-021-00575-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Letter to the Editor
Daix, Thomas
Jeannet, Robin
Hernandez Padilla, Ana Catalina
Vignon, Philippe
Feuillard, Jean
François, Bruno
Immature granulocytes can help the diagnosis of pulmonary bacterial infections in patients with severe COVID-19 pneumonia
title Immature granulocytes can help the diagnosis of pulmonary bacterial infections in patients with severe COVID-19 pneumonia
title_full Immature granulocytes can help the diagnosis of pulmonary bacterial infections in patients with severe COVID-19 pneumonia
title_fullStr Immature granulocytes can help the diagnosis of pulmonary bacterial infections in patients with severe COVID-19 pneumonia
title_full_unstemmed Immature granulocytes can help the diagnosis of pulmonary bacterial infections in patients with severe COVID-19 pneumonia
title_short Immature granulocytes can help the diagnosis of pulmonary bacterial infections in patients with severe COVID-19 pneumonia
title_sort immature granulocytes can help the diagnosis of pulmonary bacterial infections in patients with severe covid-19 pneumonia
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451732/
https://www.ncbi.nlm.nih.gov/pubmed/34544474
http://dx.doi.org/10.1186/s40560-021-00575-3
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