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A human receptor occupancy assay to measure anti‐PD‐1 binding in patients with prior anti‐PD‐1

Receptor occupancy (RO) assessment by flow cytometry is an important pharmacodynamic (PD) biomarker in the clinical development of large molecules such as monoclonal therapeutic antibodies (mAbs). The total‐drug‐bound RO assay format directly assesses mAb binding to cell surface targets using anti‐d...

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Detalles Bibliográficos
Autores principales:	Junker, Fabian, Gulati, Pratiksha, Wessels, Uwe, Seeber, Stefan, Stubenrauch, Kay‐Gunnar, Codarri‐Deak, Laura, Markert, Christoph, Klein, Christian, Camillo Teixeira, Priscila, Kao, Henry
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451911/ https://www.ncbi.nlm.nih.gov/pubmed/33704890 http://dx.doi.org/10.1002/cyto.a.24334

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