Y705 and S727 are required for the mitochondrial import and transcriptional activities of STAT3, and for regulation of stem cell proliferation

The STAT3 transcription factor, acting both in the nucleus and mitochondria, maintains embryonic stem cell pluripotency and promotes their proliferation. In this work, using zebrafish, we determined in vivo that mitochondrial STAT3 regulates mtDNA transcription in embryonic and larval stem cell nich...

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Detalles Bibliográficos
Autores principales: Peron, Margherita, Dinarello, Alberto, Meneghetti, Giacomo, Martorano, Laura, Betto, Riccardo M., Facchinello, Nicola, Tesoriere, Annachiara, Tiso, Natascia, Martello, Graziano, Argenton, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Stem Cells and Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451946/
https://www.ncbi.nlm.nih.gov/pubmed/34473253
http://dx.doi.org/10.1242/dev.199477

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