Cargando…

Synthetic lethality-based prediction of anti-SARS-CoV-2 targets

Mostrar otras versiones (1)

Novel strategies are needed to identify drug targets and treatments for the COVID-19 pandemic. The altered gene expression of virus-infected host cells provides an opportunity to specifically inhibit viral propagation via targeting the synthetic lethal (SL) partners of such altered host genes. Pursu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pal, Lipika R., Cheng, Kuoyuan, Nair, Nishanth Ulhas, Martin-Sancho, Laura, Sinha, Sanju, Pu, Yuan, Riva, Laura, Yin, Xin, Schischlik, Fiorella, Lee, Joo Sang, Chanda, Sumit K., Ruppin, Eytan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452092/ https://www.ncbi.nlm.nih.gov/pubmed/34545363 http://dx.doi.org/10.1101/2021.09.14.460408

Ejemplares similares

Synthetic lethality-based prediction of anti-SARS-CoV-2 targets
por: Pal, Lipika R., et al.
Publicado: (2022)

Genome‐scale metabolic modeling reveals SARS‐CoV‐2‐induced metabolic changes and antiviral targets
por: Cheng, Kuoyuan, et al.
Publicado: (2021)

Genome-scale metabolic modeling reveals SARS-CoV-2-induced metabolic changes and antiviral targets
por: Cheng, Kuoyuan, et al.
Publicado: (2021)

Synthetic lethality across normal tissues is strongly associated with cancer risk, onset, and tumor suppressor specificity
por: Cheng, Kuoyuan, et al.
Publicado: (2021)

Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis
por: Verma, Nandini, et al.
Publicado: (2020)

Cross-species identification of cancer resistance–associated genes that may mediate human cancer risk
por: Nair, Nishanth Ulhas, et al.
Publicado: (2022)

The landscape of receptor-mediated precision cancer combination therapy via a single-cell perspective
por: Ahmadi, Saba, et al.
Publicado: (2022)

In vitro and in vivo identification of clinically approved drugs that modify ACE2 expression
por: Sinha, Sanju, et al.
Publicado: (2020)

Moving ahead on harnessing synthetic lethality to fight cancer
por: Jerby-Arnon, Livnat, et al.
Publicado: (2015)

Harnessing synthetic lethality to predict the response to cancer treatment
por: Lee, Joo Sang, et al.
Publicado: (2018)

Identification of drugs associated with reduced severity of COVID-19: A case-control study in a large population
por: Israel, Ariel, et al.
Publicado: (2021)

Identification of drugs associated with reduced severity of COVID-19 – a case-control study in a large population
por: Israel, Ariel, et al.
Publicado: (2021)

Sex Biases in Cancer and Autoimmune Disease Incidence Are Strongly Positively Correlated with Mitochondrial Gene Expression across Human Tissues
por: Crawford, David R., et al.
Publicado: (2022)

Putative functional genes in idiopathic dilated cardiomyopathy
por: Nair, Nishanth Ulhas, et al.
Publicado: (2018)

A systematic genome-wide mapping of oncogenic mutation selection during CRISPR-Cas9 genome editing
por: Sinha, Sanju, et al.
Publicado: (2021)

Author Correction: A systematic genome-wide mapping of oncogenic mutation selection during CRISPR-Cas9 genome editing
por: Sinha, Sanju, et al.
Publicado: (2022)

Big data in basic and translational cancer research
por: Jiang, Peng, et al.
Publicado: (2022)

Genome‐wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy
por: Sahu, Avinash Das, et al.
Publicado: (2019)

Genomic and transcriptomic analyses identify a prognostic gene signature and predict response to therapy in pleural and peritoneal mesothelioma
por: Nair, Nishanth Ulhas, et al.
Publicado: (2023)

Migration rather than proliferation transcriptomic signatures are strongly associated with breast cancer patient survival
por: Nair, Nishanth Ulhas, et al.
Publicado: (2019)

Pan-Cancer Analysis of Patient Tumor Single-Cell Transcriptomes Identifies Promising Selective and Safe Chimeric Antigen Receptor Targets in Head and Neck Cancer
por: Madan, Sanna, et al.
Publicado: (2023)

Immune Determinants of the Association between Tumor Mutational Burden and Immunotherapy Response across Cancer Types
por: Sinha, Neelam, et al.
Publicado: (2022)

Modeling synthetic lethality
por: Le Meur, Nolwenn, et al.
Publicado: (2008)

Rapid Inhibitor Discovery by Exploiting Synthetic Lethality
por: Muscato, Jacob D., et al.
Publicado: (2022)

DNA repair and synthetic lethality
por: Guo, Gong-she, et al.
Publicado: (2011)

Synthetic Lethality in Ovarian Cancer
por: Chandrasekaran, Akshaya, et al.
Publicado: (2021)

Protease Addiction and Synthetic Lethality in Cancer
por: Freije, José M. P., et al.
Publicado: (2011)

Defeat mutant KRAS with synthetic lethality
por: Pang, Xiufeng, et al.
Publicado: (2016)

Protocol for Comprehensive Synthetic Lethality Screens
por: Romero-Moya, Damia, et al.
Publicado: (2020)

The tumor therapy landscape of synthetic lethality
por: Zhang, Biyu, et al.
Publicado: (2021)

Overview of Ferroptosis and Synthetic Lethality Strategies
por: Kinowaki, Yuko, et al.
Publicado: (2021)

Synthetic Lethality Targeting Polθ
por: Drzewiecka, Małgorzata, et al.
Publicado: (2022)

A maximum-likelihood approach for building cell-type trees by lifting
por: Nair, Nishanth Ulhas, et al.
Publicado: (2016)

Development of Metabolic Synthetic Lethality and Its Implications for Thyroid Cancer
por: Ju, Sang-Hyeon, et al.
Publicado: (2022)

ChIPnorm: A Statistical Method for Normalizing and Identifying Differential Regions in Histone Modification ChIP-seq Libraries
por: Nair, Nishanth Ulhas, et al.
Publicado: (2012)

Clinically oriented prediction of patient response to targeted and immunotherapies from the tumor transcriptome
por: Dinstag, Gal, et al.
Publicado: (2023)

Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets
por: Vann, Kendra R., et al.
Publicado: (2020)

Development of Synthetic Lethality Anticancer Therapeutics: Miniperspective
por: Fang, Bingliang
Publicado: (2014)

Approaches to Identifying Synthetic Lethal Interactions in Cancer
por: Thompson, Jordan M., et al.
Publicado: (2015)

Synthetically Lethal Nanoparticles for Treatment of Endometrial Cancer
por: Ebeid, Kareem, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_5f6f0uo9f0q2n6g73npkp04gt0