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Deciphering the role of nanoparticles for management of bacterial meningitis: an update on recent studies
Meningitis is an inflammation of the protective membranes called meninges and fluid adjacent the brain and spinal cord. The inflammatory progression expands all through subarachnoid space of the brain and spinal cord and occupies the ventricles. The pathogens like bacteria, fungi, viruses, or parasi...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452126/ https://www.ncbi.nlm.nih.gov/pubmed/34545518 http://dx.doi.org/10.1007/s11356-021-16570-y |
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author | Sharma, Neelam Zahoor, Ishrat Sachdeva, Monika Subramaniyan, Vetriselvan Fuloria, Shivkanya Fuloria, Neeraj Kumar Naved, Tanveer Bhatia, Saurabh Al-Harrasi, Ahmed Aleya, Lotfi Bungau, Simona Behl, Tapan Singh, Sukhbir |
author_facet | Sharma, Neelam Zahoor, Ishrat Sachdeva, Monika Subramaniyan, Vetriselvan Fuloria, Shivkanya Fuloria, Neeraj Kumar Naved, Tanveer Bhatia, Saurabh Al-Harrasi, Ahmed Aleya, Lotfi Bungau, Simona Behl, Tapan Singh, Sukhbir |
author_sort | Sharma, Neelam |
collection | PubMed |
description | Meningitis is an inflammation of the protective membranes called meninges and fluid adjacent the brain and spinal cord. The inflammatory progression expands all through subarachnoid space of the brain and spinal cord and occupies the ventricles. The pathogens like bacteria, fungi, viruses, or parasites are main sources of infection causing meningitis. Bacterial meningitis is a life-threatening health problem that which needs instantaneous apprehension and treatment. Nesseria meningitidis, Streptococcus pneumoniae, and Haemophilus flu are major widespread factors causing bacterial meningitis. The conventional drug delivery approaches encounter difficulty in crossing this blood-brain barrier (BBB) and therefore are insufficient to elicit the desired pharmacological effect as required for treatment of meningitis. Therefore, application of nanoparticle-based drug delivery systems has become imperative for successful dealing with this deadly disease. The nanoparticles have ability to across BBB via four important transport mechanisms, i.e., paracellular transport, transcellular (transcytosis), endocytosis (adsorptive transcytosis), and receptor-mediated transcytosis. In this review, we reminisce distinctive symptoms of meningitis, and provide an overview of various types of bacterial meningitis, with a focus on its epidemiology, pathogenesis, and pathophysiology. This review describes conventional therapeutic approaches for treatment of meningitis and the problems encountered by them while transmitting across tight junctions of BBB. The nanotechnology approaches like functionalized polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carrier, nanoemulsion, liposomes, transferosomes, and carbon nanotubes which have been recently evaluated for treatment or detection of bacterial meningitis have been focused. This review has also briefly summarized the recent patents and clinical status of therapeutic modalities for meningitis. |
format | Online Article Text |
id | pubmed-8452126 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-84521262021-09-21 Deciphering the role of nanoparticles for management of bacterial meningitis: an update on recent studies Sharma, Neelam Zahoor, Ishrat Sachdeva, Monika Subramaniyan, Vetriselvan Fuloria, Shivkanya Fuloria, Neeraj Kumar Naved, Tanveer Bhatia, Saurabh Al-Harrasi, Ahmed Aleya, Lotfi Bungau, Simona Behl, Tapan Singh, Sukhbir Environ Sci Pollut Res Int Review Article Meningitis is an inflammation of the protective membranes called meninges and fluid adjacent the brain and spinal cord. The inflammatory progression expands all through subarachnoid space of the brain and spinal cord and occupies the ventricles. The pathogens like bacteria, fungi, viruses, or parasites are main sources of infection causing meningitis. Bacterial meningitis is a life-threatening health problem that which needs instantaneous apprehension and treatment. Nesseria meningitidis, Streptococcus pneumoniae, and Haemophilus flu are major widespread factors causing bacterial meningitis. The conventional drug delivery approaches encounter difficulty in crossing this blood-brain barrier (BBB) and therefore are insufficient to elicit the desired pharmacological effect as required for treatment of meningitis. Therefore, application of nanoparticle-based drug delivery systems has become imperative for successful dealing with this deadly disease. The nanoparticles have ability to across BBB via four important transport mechanisms, i.e., paracellular transport, transcellular (transcytosis), endocytosis (adsorptive transcytosis), and receptor-mediated transcytosis. In this review, we reminisce distinctive symptoms of meningitis, and provide an overview of various types of bacterial meningitis, with a focus on its epidemiology, pathogenesis, and pathophysiology. This review describes conventional therapeutic approaches for treatment of meningitis and the problems encountered by them while transmitting across tight junctions of BBB. The nanotechnology approaches like functionalized polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carrier, nanoemulsion, liposomes, transferosomes, and carbon nanotubes which have been recently evaluated for treatment or detection of bacterial meningitis have been focused. This review has also briefly summarized the recent patents and clinical status of therapeutic modalities for meningitis. Springer Berlin Heidelberg 2021-09-20 2021 /pmc/articles/PMC8452126/ /pubmed/34545518 http://dx.doi.org/10.1007/s11356-021-16570-y Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Article Sharma, Neelam Zahoor, Ishrat Sachdeva, Monika Subramaniyan, Vetriselvan Fuloria, Shivkanya Fuloria, Neeraj Kumar Naved, Tanveer Bhatia, Saurabh Al-Harrasi, Ahmed Aleya, Lotfi Bungau, Simona Behl, Tapan Singh, Sukhbir Deciphering the role of nanoparticles for management of bacterial meningitis: an update on recent studies |
title | Deciphering the role of nanoparticles for management of bacterial meningitis: an update on recent studies |
title_full | Deciphering the role of nanoparticles for management of bacterial meningitis: an update on recent studies |
title_fullStr | Deciphering the role of nanoparticles for management of bacterial meningitis: an update on recent studies |
title_full_unstemmed | Deciphering the role of nanoparticles for management of bacterial meningitis: an update on recent studies |
title_short | Deciphering the role of nanoparticles for management of bacterial meningitis: an update on recent studies |
title_sort | deciphering the role of nanoparticles for management of bacterial meningitis: an update on recent studies |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452126/ https://www.ncbi.nlm.nih.gov/pubmed/34545518 http://dx.doi.org/10.1007/s11356-021-16570-y |
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