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Persistent Purine Metabolic Abnormality Induces the Aggravation of Visceral Inflammation and Intestinal Microbiota Dysbiosis in Magang Goose

Gout is a disease involving abnormal purine metabolism that is widespread in mammals and birds. Goose is especially susceptible for gout in early stage. However, a few studies investigated the ontogenetic pattern of goslings with purine metabolic abnormality. Our studies were conducted to investigat...

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Autores principales: Ma, Weiqing, Zhou, Lingjuan, Li, Yu, Xia, Daiyang, Chen, Jianying, Chen, Junpeng, Jiang, Xianzhi, Qin, Jiangfan, Zhao, Yujie, Zhang, Xiufen, Wang, Heng, Fu, Yang, Zhu, Shanshan, Jiang, Huiquan, Ye, Hui, Zhu, Yongwen, Lin, Zhenping, Wang, Wence, Yang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452157/
https://www.ncbi.nlm.nih.gov/pubmed/34552978
http://dx.doi.org/10.3389/fvets.2021.737160
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author Ma, Weiqing
Zhou, Lingjuan
Li, Yu
Xia, Daiyang
Chen, Jianying
Chen, Junpeng
Jiang, Xianzhi
Qin, Jiangfan
Zhao, Yujie
Zhang, Xiufen
Wang, Heng
Fu, Yang
Zhu, Shanshan
Jiang, Huiquan
Ye, Hui
Zhu, Yongwen
Lin, Zhenping
Wang, Wence
Yang, Lin
author_facet Ma, Weiqing
Zhou, Lingjuan
Li, Yu
Xia, Daiyang
Chen, Jianying
Chen, Junpeng
Jiang, Xianzhi
Qin, Jiangfan
Zhao, Yujie
Zhang, Xiufen
Wang, Heng
Fu, Yang
Zhu, Shanshan
Jiang, Huiquan
Ye, Hui
Zhu, Yongwen
Lin, Zhenping
Wang, Wence
Yang, Lin
author_sort Ma, Weiqing
collection PubMed
description Gout is a disease involving abnormal purine metabolism that is widespread in mammals and birds. Goose is especially susceptible for gout in early stage. However, a few studies investigated the ontogenetic pattern of goslings with purine metabolic abnormality. Our studies were conducted to investigate whether persistent purine metabolic abnormality would lead to aggravation of visceral inflammation and intestinal microbiota dysbiosis in goose. A total of 132 1-day-old Magang geese were randomly divided into six replicates and fed a high-calcium and protein meal-based diet from 1 to 28 days. The experiment lasted for 28 days. Liver and kidney damages were observed in 14- and 28-day-old Magang geese, and liver inflammation increased with increasing age. In 28-day-old Magang geese, serum CAT and liver GSH-Px activity were significantly reduced. Furthermore, jejunum intestinal barrier was impaired and the abundance of Bacteroides was significantly reduced at the genus level. Collectively, the high-calcium and high-protein (HCP) meal-based diet caused liver and kidney damage in 28-day-old Magang geese, leading to hyperuricemia and gout symptoms, and the intestinal barrier is impaired and the intestinal flora is disrupted.
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spelling pubmed-84521572021-09-21 Persistent Purine Metabolic Abnormality Induces the Aggravation of Visceral Inflammation and Intestinal Microbiota Dysbiosis in Magang Goose Ma, Weiqing Zhou, Lingjuan Li, Yu Xia, Daiyang Chen, Jianying Chen, Junpeng Jiang, Xianzhi Qin, Jiangfan Zhao, Yujie Zhang, Xiufen Wang, Heng Fu, Yang Zhu, Shanshan Jiang, Huiquan Ye, Hui Zhu, Yongwen Lin, Zhenping Wang, Wence Yang, Lin Front Vet Sci Veterinary Science Gout is a disease involving abnormal purine metabolism that is widespread in mammals and birds. Goose is especially susceptible for gout in early stage. However, a few studies investigated the ontogenetic pattern of goslings with purine metabolic abnormality. Our studies were conducted to investigate whether persistent purine metabolic abnormality would lead to aggravation of visceral inflammation and intestinal microbiota dysbiosis in goose. A total of 132 1-day-old Magang geese were randomly divided into six replicates and fed a high-calcium and protein meal-based diet from 1 to 28 days. The experiment lasted for 28 days. Liver and kidney damages were observed in 14- and 28-day-old Magang geese, and liver inflammation increased with increasing age. In 28-day-old Magang geese, serum CAT and liver GSH-Px activity were significantly reduced. Furthermore, jejunum intestinal barrier was impaired and the abundance of Bacteroides was significantly reduced at the genus level. Collectively, the high-calcium and high-protein (HCP) meal-based diet caused liver and kidney damage in 28-day-old Magang geese, leading to hyperuricemia and gout symptoms, and the intestinal barrier is impaired and the intestinal flora is disrupted. Frontiers Media S.A. 2021-09-06 /pmc/articles/PMC8452157/ /pubmed/34552978 http://dx.doi.org/10.3389/fvets.2021.737160 Text en Copyright © 2021 Ma, Zhou, Li, Xia, Chen, Chen, Jiang, Qin, Zhao, Zhang, Wang, Fu, Zhu, Jiang, Ye, Zhu, Lin, Wang and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Ma, Weiqing
Zhou, Lingjuan
Li, Yu
Xia, Daiyang
Chen, Jianying
Chen, Junpeng
Jiang, Xianzhi
Qin, Jiangfan
Zhao, Yujie
Zhang, Xiufen
Wang, Heng
Fu, Yang
Zhu, Shanshan
Jiang, Huiquan
Ye, Hui
Zhu, Yongwen
Lin, Zhenping
Wang, Wence
Yang, Lin
Persistent Purine Metabolic Abnormality Induces the Aggravation of Visceral Inflammation and Intestinal Microbiota Dysbiosis in Magang Goose
title Persistent Purine Metabolic Abnormality Induces the Aggravation of Visceral Inflammation and Intestinal Microbiota Dysbiosis in Magang Goose
title_full Persistent Purine Metabolic Abnormality Induces the Aggravation of Visceral Inflammation and Intestinal Microbiota Dysbiosis in Magang Goose
title_fullStr Persistent Purine Metabolic Abnormality Induces the Aggravation of Visceral Inflammation and Intestinal Microbiota Dysbiosis in Magang Goose
title_full_unstemmed Persistent Purine Metabolic Abnormality Induces the Aggravation of Visceral Inflammation and Intestinal Microbiota Dysbiosis in Magang Goose
title_short Persistent Purine Metabolic Abnormality Induces the Aggravation of Visceral Inflammation and Intestinal Microbiota Dysbiosis in Magang Goose
title_sort persistent purine metabolic abnormality induces the aggravation of visceral inflammation and intestinal microbiota dysbiosis in magang goose
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452157/
https://www.ncbi.nlm.nih.gov/pubmed/34552978
http://dx.doi.org/10.3389/fvets.2021.737160
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