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Functionally graded membrane: A novel approach in the treatment of gingival recession defects

BACKGROUND: Guided tissue regeneration has recently been advocated in re-constructing soft-tissue dimensions in recession defects. Advancement in nanotechnology has led to increased zest for approaches such as electrospinning of biologically active; nanofibrous functionally graded regenerative membr...

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Autores principales: Dhawan, Shivani, Takiar, Megha, Manocha, Anish, Dhawan, Rajan, Malhotra, Ranjan, Gupta, Jyoti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452168/
https://www.ncbi.nlm.nih.gov/pubmed/34667384
http://dx.doi.org/10.4103/jisp.jisp_583_20
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author Dhawan, Shivani
Takiar, Megha
Manocha, Anish
Dhawan, Rajan
Malhotra, Ranjan
Gupta, Jyoti
author_facet Dhawan, Shivani
Takiar, Megha
Manocha, Anish
Dhawan, Rajan
Malhotra, Ranjan
Gupta, Jyoti
author_sort Dhawan, Shivani
collection PubMed
description BACKGROUND: Guided tissue regeneration has recently been advocated in re-constructing soft-tissue dimensions in recession defects. Advancement in nanotechnology has led to increased zest for approaches such as electrospinning of biologically active; nanofibrous functionally graded regenerative membranes for periodontal tissue engineering. A functionally graded membrane (FGM) had been tailored by incorporating chitosan and nano-hydroxyapatite over Amnion membrane and used in gingival recession defects. STUDY DESIGN: It was single-blind, randomized controlled study. Split-mouth study was conducted in nine patients and 22 sites with recession defects were selected. Sites were divided into Group A (Amnion membrane with coronal advanced flap) and Group B (FGM with coronal advanced flap). MATERIALS AND METHODS: Sites were assessed clinically by recording plaque index (PI), gingival index (GI), vertical recession defect depth (VRDD), relative clinical attachment level (CAL), and width of keratinized tissue at baseline, 3–6 months; and radiographically by recording linear bone growth by dentascan at baseline and 6 months. RESULT: Both groups showed statistically significant reduction in PI, GI and VRDD, and CAL and nonsignificant reduction in width of keratinized tissue at 3 and 6 months postoperatively. Group A showed statistically significant linear bone growth at 6 months. Group B also showed gain in linear bone growth at 6 months; however, result was statistically nonsignificant. CONCLUSION: FGM had shown favorable results by enhancing bone growth while preventing the gingival tissue downgrowth.
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spelling pubmed-84521682021-10-18 Functionally graded membrane: A novel approach in the treatment of gingival recession defects Dhawan, Shivani Takiar, Megha Manocha, Anish Dhawan, Rajan Malhotra, Ranjan Gupta, Jyoti J Indian Soc Periodontol Original Article BACKGROUND: Guided tissue regeneration has recently been advocated in re-constructing soft-tissue dimensions in recession defects. Advancement in nanotechnology has led to increased zest for approaches such as electrospinning of biologically active; nanofibrous functionally graded regenerative membranes for periodontal tissue engineering. A functionally graded membrane (FGM) had been tailored by incorporating chitosan and nano-hydroxyapatite over Amnion membrane and used in gingival recession defects. STUDY DESIGN: It was single-blind, randomized controlled study. Split-mouth study was conducted in nine patients and 22 sites with recession defects were selected. Sites were divided into Group A (Amnion membrane with coronal advanced flap) and Group B (FGM with coronal advanced flap). MATERIALS AND METHODS: Sites were assessed clinically by recording plaque index (PI), gingival index (GI), vertical recession defect depth (VRDD), relative clinical attachment level (CAL), and width of keratinized tissue at baseline, 3–6 months; and radiographically by recording linear bone growth by dentascan at baseline and 6 months. RESULT: Both groups showed statistically significant reduction in PI, GI and VRDD, and CAL and nonsignificant reduction in width of keratinized tissue at 3 and 6 months postoperatively. Group A showed statistically significant linear bone growth at 6 months. Group B also showed gain in linear bone growth at 6 months; however, result was statistically nonsignificant. CONCLUSION: FGM had shown favorable results by enhancing bone growth while preventing the gingival tissue downgrowth. Wolters Kluwer - Medknow 2021 2021-08-30 /pmc/articles/PMC8452168/ /pubmed/34667384 http://dx.doi.org/10.4103/jisp.jisp_583_20 Text en Copyright: © 2021 Indian Society of Periodontology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Dhawan, Shivani
Takiar, Megha
Manocha, Anish
Dhawan, Rajan
Malhotra, Ranjan
Gupta, Jyoti
Functionally graded membrane: A novel approach in the treatment of gingival recession defects
title Functionally graded membrane: A novel approach in the treatment of gingival recession defects
title_full Functionally graded membrane: A novel approach in the treatment of gingival recession defects
title_fullStr Functionally graded membrane: A novel approach in the treatment of gingival recession defects
title_full_unstemmed Functionally graded membrane: A novel approach in the treatment of gingival recession defects
title_short Functionally graded membrane: A novel approach in the treatment of gingival recession defects
title_sort functionally graded membrane: a novel approach in the treatment of gingival recession defects
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452168/
https://www.ncbi.nlm.nih.gov/pubmed/34667384
http://dx.doi.org/10.4103/jisp.jisp_583_20
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