Quantitative prediction of breast cancer resistant protein mediated drug‐drug interactions using physiologically‐based pharmacokinetic modeling

Quantitative assessment of drug‐drug interactions (DDIs) involving breast cancer resistance protein (BCRP) inhibition is challenged by overlapping substrate/inhibitor specificity. This study used physiologically‐based pharmacokinetic (PBPK) modeling to delineate the effects of inhibitor drugs on BCR...

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Detalles Bibliográficos
Autores principales: Costales, Chester, Lin, Jian, Kimoto, Emi, Yamazaki, Shinji, Gosset, James R., Rodrigues, A. David, Lazzaro, Sarah, West, Mark A., West, Michael, Varma, Manthena V. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452302/
https://www.ncbi.nlm.nih.gov/pubmed/34164937
http://dx.doi.org/10.1002/psp4.12672

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