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Blood pressure in adults with cerebral palsy: a systematic review and meta-analysis of individual participant data

OBJECTIVES: This systematic review and meta-analysis was designed to determine the overall mean blood pressure and prevalence of hypertension among a representative sample of adults living with cerebral palsy by combining individual participant data. Additional objectives included estimating variati...

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Autores principales: Noten, Suzie, van den Berg-Emons, Rita J.G., Thorpe, Deborah E., Heyn, Patricia C., Marciniak, Christina M., McPhee, Patrick G., Lamberts, Robert P., Langerak, Nelleke G., Verschuren, Olaf, Salokivi, Tommi, Morrison, Katherine M., Peterson, Mark D., Limsakul, Chonnanid, Stam, Henk J., Papageorgiou, Grigorios, Versmissen, Jorie, Van Der Slot, Wilma M.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452335/
https://www.ncbi.nlm.nih.gov/pubmed/34102658
http://dx.doi.org/10.1097/HJH.0000000000002912
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author Noten, Suzie
van den Berg-Emons, Rita J.G.
Thorpe, Deborah E.
Heyn, Patricia C.
Marciniak, Christina M.
McPhee, Patrick G.
Lamberts, Robert P.
Langerak, Nelleke G.
Verschuren, Olaf
Salokivi, Tommi
Morrison, Katherine M.
Peterson, Mark D.
Limsakul, Chonnanid
Stam, Henk J.
Papageorgiou, Grigorios
Versmissen, Jorie
Van Der Slot, Wilma M.A.
author_facet Noten, Suzie
van den Berg-Emons, Rita J.G.
Thorpe, Deborah E.
Heyn, Patricia C.
Marciniak, Christina M.
McPhee, Patrick G.
Lamberts, Robert P.
Langerak, Nelleke G.
Verschuren, Olaf
Salokivi, Tommi
Morrison, Katherine M.
Peterson, Mark D.
Limsakul, Chonnanid
Stam, Henk J.
Papageorgiou, Grigorios
Versmissen, Jorie
Van Der Slot, Wilma M.A.
author_sort Noten, Suzie
collection PubMed
description OBJECTIVES: This systematic review and meta-analysis was designed to determine the overall mean blood pressure and prevalence of hypertension among a representative sample of adults living with cerebral palsy by combining individual participant data. Additional objectives included estimating variations between subgroups and investigating potential risk factors for hypertension. METHODS: Potential datasets were identified by literature searches for studies published between January 2000 and November 2017 and by experts in the field. Samples of adults with cerebral palsy (n ≥ 10, age ≥ 18 years) were included if blood pressure data, cerebral palsy-related factors (e.g. cerebral palsy subtype), and sociodemographic variables (e.g. age, sex) were available. Hypertension was defined as at least 140/90 mmHg and/or use of antihypertensive medication. RESULTS: We included data from 11 international cohorts representing 444 adults with cerebral palsy [median (IQR) age of the sample was 29.0 (23.0–38.0); 51% men; 89% spastic type; Gross Motor Function Classification System levels I–V]. Overall mean SBP was 124.9 mmHg [95% confidence interval (CI) 121.7–128.1] and overall mean DBP was 79.9 mmHg (95% CI 77.2–82.5). Overall prevalence of hypertension was 28.7% (95% CI 18.8–39.8%). Subgroup analysis indicated higher blood pressure levels or higher prevalence of hypertension in adults with cerebral palsy above 40 years of age, men, those with spastic cerebral palsy or those who lived in Africa. BMI, resting heart rate and alcohol consumption were risk factors that were associated with blood pressure or hypertension. CONCLUSION: Our findings underscore the importance of clinical screening for blood pressure in individuals with cerebral palsy beginning in young adulthood.
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spelling pubmed-84523352021-09-28 Blood pressure in adults with cerebral palsy: a systematic review and meta-analysis of individual participant data Noten, Suzie van den Berg-Emons, Rita J.G. Thorpe, Deborah E. Heyn, Patricia C. Marciniak, Christina M. McPhee, Patrick G. Lamberts, Robert P. Langerak, Nelleke G. Verschuren, Olaf Salokivi, Tommi Morrison, Katherine M. Peterson, Mark D. Limsakul, Chonnanid Stam, Henk J. Papageorgiou, Grigorios Versmissen, Jorie Van Der Slot, Wilma M.A. J Hypertens Reviews and Meta-Analyses OBJECTIVES: This systematic review and meta-analysis was designed to determine the overall mean blood pressure and prevalence of hypertension among a representative sample of adults living with cerebral palsy by combining individual participant data. Additional objectives included estimating variations between subgroups and investigating potential risk factors for hypertension. METHODS: Potential datasets were identified by literature searches for studies published between January 2000 and November 2017 and by experts in the field. Samples of adults with cerebral palsy (n ≥ 10, age ≥ 18 years) were included if blood pressure data, cerebral palsy-related factors (e.g. cerebral palsy subtype), and sociodemographic variables (e.g. age, sex) were available. Hypertension was defined as at least 140/90 mmHg and/or use of antihypertensive medication. RESULTS: We included data from 11 international cohorts representing 444 adults with cerebral palsy [median (IQR) age of the sample was 29.0 (23.0–38.0); 51% men; 89% spastic type; Gross Motor Function Classification System levels I–V]. Overall mean SBP was 124.9 mmHg [95% confidence interval (CI) 121.7–128.1] and overall mean DBP was 79.9 mmHg (95% CI 77.2–82.5). Overall prevalence of hypertension was 28.7% (95% CI 18.8–39.8%). Subgroup analysis indicated higher blood pressure levels or higher prevalence of hypertension in adults with cerebral palsy above 40 years of age, men, those with spastic cerebral palsy or those who lived in Africa. BMI, resting heart rate and alcohol consumption were risk factors that were associated with blood pressure or hypertension. CONCLUSION: Our findings underscore the importance of clinical screening for blood pressure in individuals with cerebral palsy beginning in young adulthood. Lippincott Williams & Wilkins 2021-10 2021-06-07 /pmc/articles/PMC8452335/ /pubmed/34102658 http://dx.doi.org/10.1097/HJH.0000000000002912 Text en Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Reviews and Meta-Analyses
Noten, Suzie
van den Berg-Emons, Rita J.G.
Thorpe, Deborah E.
Heyn, Patricia C.
Marciniak, Christina M.
McPhee, Patrick G.
Lamberts, Robert P.
Langerak, Nelleke G.
Verschuren, Olaf
Salokivi, Tommi
Morrison, Katherine M.
Peterson, Mark D.
Limsakul, Chonnanid
Stam, Henk J.
Papageorgiou, Grigorios
Versmissen, Jorie
Van Der Slot, Wilma M.A.
Blood pressure in adults with cerebral palsy: a systematic review and meta-analysis of individual participant data
title Blood pressure in adults with cerebral palsy: a systematic review and meta-analysis of individual participant data
title_full Blood pressure in adults with cerebral palsy: a systematic review and meta-analysis of individual participant data
title_fullStr Blood pressure in adults with cerebral palsy: a systematic review and meta-analysis of individual participant data
title_full_unstemmed Blood pressure in adults with cerebral palsy: a systematic review and meta-analysis of individual participant data
title_short Blood pressure in adults with cerebral palsy: a systematic review and meta-analysis of individual participant data
title_sort blood pressure in adults with cerebral palsy: a systematic review and meta-analysis of individual participant data
topic Reviews and Meta-Analyses
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452335/
https://www.ncbi.nlm.nih.gov/pubmed/34102658
http://dx.doi.org/10.1097/HJH.0000000000002912
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