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Development and Application of 3D Bioprinted Scaffolds Supporting Induced Pluripotent Stem Cells
Three-dimensional (3D) bioprinting is a revolutionary technology that replicates 3D functional living tissue scaffolds in vitro by controlling the layer-by-layer deposition of biomaterials and enables highly precise positioning of cells. With the development of this technology, more advanced researc...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452409/ https://www.ncbi.nlm.nih.gov/pubmed/34552987 http://dx.doi.org/10.1155/2021/4910816 |
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author | Lu, Dezhi Liu, Yang Li, Wentao Ma, Hongshi Li, Tao Ma, Xiaojun Mao, Yuanqing Liang, Qianqian Ma, Zhenjiang Wang, Jinwu |
author_facet | Lu, Dezhi Liu, Yang Li, Wentao Ma, Hongshi Li, Tao Ma, Xiaojun Mao, Yuanqing Liang, Qianqian Ma, Zhenjiang Wang, Jinwu |
author_sort | Lu, Dezhi |
collection | PubMed |
description | Three-dimensional (3D) bioprinting is a revolutionary technology that replicates 3D functional living tissue scaffolds in vitro by controlling the layer-by-layer deposition of biomaterials and enables highly precise positioning of cells. With the development of this technology, more advanced research on the mechanisms of tissue morphogenesis, clinical drug screening, and organ regeneration may be pursued. Because of their self-renewal characteristics and multidirectional differentiation potential, induced pluripotent stem cells (iPSCs) have outstanding advantages in stem cell research and applications. In this review, we discuss the advantages of different bioinks containing human iPSCs that are fabricated by using 3D bioprinting. In particular, we focus on the ability of these bioinks to support iPSCs and promote their proliferation and differentiation. In addition, we summarize the applications of 3D bioprinting with iPSC-containing bioinks and put forward new views on the current research status. |
format | Online Article Text |
id | pubmed-8452409 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-84524092021-09-21 Development and Application of 3D Bioprinted Scaffolds Supporting Induced Pluripotent Stem Cells Lu, Dezhi Liu, Yang Li, Wentao Ma, Hongshi Li, Tao Ma, Xiaojun Mao, Yuanqing Liang, Qianqian Ma, Zhenjiang Wang, Jinwu Biomed Res Int Review Article Three-dimensional (3D) bioprinting is a revolutionary technology that replicates 3D functional living tissue scaffolds in vitro by controlling the layer-by-layer deposition of biomaterials and enables highly precise positioning of cells. With the development of this technology, more advanced research on the mechanisms of tissue morphogenesis, clinical drug screening, and organ regeneration may be pursued. Because of their self-renewal characteristics and multidirectional differentiation potential, induced pluripotent stem cells (iPSCs) have outstanding advantages in stem cell research and applications. In this review, we discuss the advantages of different bioinks containing human iPSCs that are fabricated by using 3D bioprinting. In particular, we focus on the ability of these bioinks to support iPSCs and promote their proliferation and differentiation. In addition, we summarize the applications of 3D bioprinting with iPSC-containing bioinks and put forward new views on the current research status. Hindawi 2021-09-13 /pmc/articles/PMC8452409/ /pubmed/34552987 http://dx.doi.org/10.1155/2021/4910816 Text en Copyright © 2021 Dezhi Lu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Lu, Dezhi Liu, Yang Li, Wentao Ma, Hongshi Li, Tao Ma, Xiaojun Mao, Yuanqing Liang, Qianqian Ma, Zhenjiang Wang, Jinwu Development and Application of 3D Bioprinted Scaffolds Supporting Induced Pluripotent Stem Cells |
title | Development and Application of 3D Bioprinted Scaffolds Supporting Induced Pluripotent Stem Cells |
title_full | Development and Application of 3D Bioprinted Scaffolds Supporting Induced Pluripotent Stem Cells |
title_fullStr | Development and Application of 3D Bioprinted Scaffolds Supporting Induced Pluripotent Stem Cells |
title_full_unstemmed | Development and Application of 3D Bioprinted Scaffolds Supporting Induced Pluripotent Stem Cells |
title_short | Development and Application of 3D Bioprinted Scaffolds Supporting Induced Pluripotent Stem Cells |
title_sort | development and application of 3d bioprinted scaffolds supporting induced pluripotent stem cells |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452409/ https://www.ncbi.nlm.nih.gov/pubmed/34552987 http://dx.doi.org/10.1155/2021/4910816 |
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