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Development and Application of 3D Bioprinted Scaffolds Supporting Induced Pluripotent Stem Cells

Three-dimensional (3D) bioprinting is a revolutionary technology that replicates 3D functional living tissue scaffolds in vitro by controlling the layer-by-layer deposition of biomaterials and enables highly precise positioning of cells. With the development of this technology, more advanced researc...

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Detalles Bibliográficos
Autores principales: Lu, Dezhi, Liu, Yang, Li, Wentao, Ma, Hongshi, Li, Tao, Ma, Xiaojun, Mao, Yuanqing, Liang, Qianqian, Ma, Zhenjiang, Wang, Jinwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452409/
https://www.ncbi.nlm.nih.gov/pubmed/34552987
http://dx.doi.org/10.1155/2021/4910816
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author Lu, Dezhi
Liu, Yang
Li, Wentao
Ma, Hongshi
Li, Tao
Ma, Xiaojun
Mao, Yuanqing
Liang, Qianqian
Ma, Zhenjiang
Wang, Jinwu
author_facet Lu, Dezhi
Liu, Yang
Li, Wentao
Ma, Hongshi
Li, Tao
Ma, Xiaojun
Mao, Yuanqing
Liang, Qianqian
Ma, Zhenjiang
Wang, Jinwu
author_sort Lu, Dezhi
collection PubMed
description Three-dimensional (3D) bioprinting is a revolutionary technology that replicates 3D functional living tissue scaffolds in vitro by controlling the layer-by-layer deposition of biomaterials and enables highly precise positioning of cells. With the development of this technology, more advanced research on the mechanisms of tissue morphogenesis, clinical drug screening, and organ regeneration may be pursued. Because of their self-renewal characteristics and multidirectional differentiation potential, induced pluripotent stem cells (iPSCs) have outstanding advantages in stem cell research and applications. In this review, we discuss the advantages of different bioinks containing human iPSCs that are fabricated by using 3D bioprinting. In particular, we focus on the ability of these bioinks to support iPSCs and promote their proliferation and differentiation. In addition, we summarize the applications of 3D bioprinting with iPSC-containing bioinks and put forward new views on the current research status.
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spelling pubmed-84524092021-09-21 Development and Application of 3D Bioprinted Scaffolds Supporting Induced Pluripotent Stem Cells Lu, Dezhi Liu, Yang Li, Wentao Ma, Hongshi Li, Tao Ma, Xiaojun Mao, Yuanqing Liang, Qianqian Ma, Zhenjiang Wang, Jinwu Biomed Res Int Review Article Three-dimensional (3D) bioprinting is a revolutionary technology that replicates 3D functional living tissue scaffolds in vitro by controlling the layer-by-layer deposition of biomaterials and enables highly precise positioning of cells. With the development of this technology, more advanced research on the mechanisms of tissue morphogenesis, clinical drug screening, and organ regeneration may be pursued. Because of their self-renewal characteristics and multidirectional differentiation potential, induced pluripotent stem cells (iPSCs) have outstanding advantages in stem cell research and applications. In this review, we discuss the advantages of different bioinks containing human iPSCs that are fabricated by using 3D bioprinting. In particular, we focus on the ability of these bioinks to support iPSCs and promote their proliferation and differentiation. In addition, we summarize the applications of 3D bioprinting with iPSC-containing bioinks and put forward new views on the current research status. Hindawi 2021-09-13 /pmc/articles/PMC8452409/ /pubmed/34552987 http://dx.doi.org/10.1155/2021/4910816 Text en Copyright © 2021 Dezhi Lu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lu, Dezhi
Liu, Yang
Li, Wentao
Ma, Hongshi
Li, Tao
Ma, Xiaojun
Mao, Yuanqing
Liang, Qianqian
Ma, Zhenjiang
Wang, Jinwu
Development and Application of 3D Bioprinted Scaffolds Supporting Induced Pluripotent Stem Cells
title Development and Application of 3D Bioprinted Scaffolds Supporting Induced Pluripotent Stem Cells
title_full Development and Application of 3D Bioprinted Scaffolds Supporting Induced Pluripotent Stem Cells
title_fullStr Development and Application of 3D Bioprinted Scaffolds Supporting Induced Pluripotent Stem Cells
title_full_unstemmed Development and Application of 3D Bioprinted Scaffolds Supporting Induced Pluripotent Stem Cells
title_short Development and Application of 3D Bioprinted Scaffolds Supporting Induced Pluripotent Stem Cells
title_sort development and application of 3d bioprinted scaffolds supporting induced pluripotent stem cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452409/
https://www.ncbi.nlm.nih.gov/pubmed/34552987
http://dx.doi.org/10.1155/2021/4910816
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