Increased tissue stiffness triggers contractile dysfunction and telomere shortening in dystrophic cardiomyocytes

Duchenne muscular dystrophy (DMD) is a rare X-linked recessive disease that is associated with severe progressive muscle degeneration culminating in death due to cardiorespiratory failure. We previously observed an unexpected proliferation-independent telomere shortening in cardiomyocytes of a DMD m...

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Detalles Bibliográficos
Autores principales: Chang, Alex C.Y., Pardon, Gaspard, Chang, Andrew C.H., Wu, Haodi, Ong, Sang-Ging, Eguchi, Asuka, Ancel, Sara, Holbrook, Colin, Ramunas, John, Ribeiro, Alexandre J.S., LaGory, Edward L., Wang, Honghui, Koleckar, Kassie, Giaccia, Amato, Mack, David L., Childers, Martin K., Denning, Chris, Day, John W., Wu, Joseph C., Pruitt, Beth L., Blau, Helen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452491/
https://www.ncbi.nlm.nih.gov/pubmed/34019816
http://dx.doi.org/10.1016/j.stemcr.2021.04.018

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