Sonlicromanol improves neuronal network dysfunction and transcriptome changes linked to m.3243A>G heteroplasmy in iPSC-derived neurons

Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is often caused by an adenine to guanine variant at m.3243 (m.3243A>G) of the MT-TL1 gene. To understand how this pathogenic variant affects the nervous system, we differentiated human induced pluripotent stem cell...

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Detalles Bibliográficos
Autores principales: Klein Gunnewiek, Teun M., Verboven, Anouk H.A., Pelgrim, Iris, Hogeweg, Mark, Schoenmaker, Chantal, Renkema, Herma, Beyrath, Julien, Smeitink, Jan, de Vries, Bert B.A., Hoen, Peter-Bram A.C. ’t, Kozicz, Tamas, Nadif Kasri, Nael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452519/
https://www.ncbi.nlm.nih.gov/pubmed/34329596
http://dx.doi.org/10.1016/j.stemcr.2021.07.002

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