De novo DNA methyltransferases DNMT3A and DNMT3B are essential for XIST silencing for erosion of dosage compensation in pluripotent stem cells

Human pluripotent stem cells (hPSCs) have proven to be valuable tools for both drug discovery and the development of cell-based therapies. However, the long non-coding RNA XIST, which is essential for the establishment and maintenance of X chromosome inactivation, is repressed during culture, thereb...

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Detalles Bibliográficos
Autores principales: Fukuda, Atsushi, Hazelbaker, Dane Z., Motosugi, Nami, Hao, Jin, Limone, Francesco, Beccard, Amanda, Mazzucato, Patrizia, Messana, Angelica, Okada, Chisa, San Juan, Irune Guerra, Qian, Menglu, Umezawa, Akihiro, Akutsu, Hidenori, Barrett, Lindy E., Eggan, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452533/
https://www.ncbi.nlm.nih.gov/pubmed/34416176
http://dx.doi.org/10.1016/j.stemcr.2021.07.015

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