The tumor suppressor WT1 drives progenitor cell progression and epithelialization to prevent Wilms tumorigenesis in human kidney organoids

Wilms tumor is the most widespread kidney cancer in children and frequently associated with homozygous loss of the tumor suppressor WT1. Pediatric tumorigenesis is largely inaccessible in humans. Here, we develop a human kidney organoid model for Wilms tumor formation and show that deletion of WT1 d...

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Detalles Bibliográficos
Autores principales: Waehle, Verena, Ungricht, Rosemarie, Hoppe, Philipp S., Betschinger, Joerg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452534/
https://www.ncbi.nlm.nih.gov/pubmed/34450039
http://dx.doi.org/10.1016/j.stemcr.2021.07.023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452534/
https://www.ncbi.nlm.nih.gov/pubmed/34450039
http://dx.doi.org/10.1016/j.stemcr.2021.07.023

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