APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation

The ε4 allele of APOE-encoding apolipoprotein (ApoE) is one of the strongest genetic risk factors for Alzheimer’s disease (AD). One of the overarching questions is whether and how this astrocyte-enriched risk factor initiates AD-associated pathology in neurons such as amyloid-β (Aβ) accumulation. He...

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Detalles Bibliográficos
Autores principales: Lee, Se-In, Jeong, Woojin, Lim, Heejin, Cho, Sukhee, Lee, Hyein, Jang, Yonghee, Cho, Joonho, Bae, Simsung, Lin, Yuan-Ta, Tsai, Li-Huei, Moon, Dae Won, Seo, Jinsoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452535/
https://www.ncbi.nlm.nih.gov/pubmed/34450034
http://dx.doi.org/10.1016/j.stemcr.2021.07.017

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